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Recombinant allergens: applications in allergy diagnosis and therapy

HomeMolekulare BiologieResearchFerreira

Type I allergies, which comprise a wide range of IgE-mediated disorders such as hay fever, asthma, atopic dermatitis, affect more than 20% of the population and therefore represents a major health problem.

The primary interest of our group is the development of new tools for allergy diagnosis and for safer and more efficient allergen-specific immunotherapy. Presently, we are working on birch pollen and associated food allergies, allergic reactions to mountain and Japanese cedar and ragweed and mugwort pollen allergies.

To generate improved tools for allergy diagnosis and therapy, our ongoing projects involve:

• Identification of natural allergens
• Generation of low IgE binding hypoallergenic molecules in bacterial,
   yeast and plant expression systems
• Protein purification
• Physicochemical protein characterization (analysis of protein folding and
  aggregation, mass spectrometry)
• Immunologic characterization of recombinant proteins in vitro
• Antigen uptake and processing
• Analysis of allergenic molecules in pre-clinical models

NEWS

Fátima Ferreira wurde am 29.06.09 zu einem Vortrag in die österreichische Botschaft nach Washington DC eingeladen.

Das FWF-Projekt "Strukturelle Merkmale und Immunogenität von Allergieimpfstoffen" wurde am 11.05.2009 im Rahmen des Translational-Research-Programms bewilligt.

Fátima Ferreira wurde vom Klub der Bildungs- und Wissenschaftsjournalisten Österreichs zur Wissenschaftlerin des Jahres 2008 gewählt.
This group is member of the international "PhD program ICA" of the University of Salzburg.
... International PhD program ICA
The group is a member of the priority programme "BioScience and Health" of the University of Salzburg.
... BioScience and Health

Christian Doppler Laboratory
for Allergy Diagnosis and Therapy

... CD Laboratory
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