2017

 

Kitzmuller C, Kalser J, Mutschlechner S, Hauser M, Zlabinger GJ, Ferreira F, Bohle B. Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity. J Allergy Clin Immunol 141: 293-299, 2018, doi: 10.1016/j.jaci.2017.02.044

Pablos I, Eichhorn S, Machado Y, Briza P, Neunkirchner A, Jahn-Schmid B, Wildner S, Soh WT, Ebner C, Park JW, Pickl W, Arora N, Vieths, S, Ferreira F, Gadermaier G. Distinct epitope structures of defensin-like proteins linked to proline-rich regions give rise to diferrences in their allergenic activity. Allergy 72: 431-441, 2018. doi: 10.1111/all.13298.

Strasser L, Dang HH, Schwarz H, Asam C, Ferreira F, Horejs-Hoeck J, Huber CG. Unbiased quantitative proteomics reveals a crucial role of the allergen context for the activation of human dendritic cells. Scientific Rep 7:16638, 2017. doi: 10.1038/s41598-017-16726

Wolf M, Aglas L, Twaroch TE, Steiner M, Huber S, Hauser M, Parigiani MA, Hofer H, Ebner C, Bohle B, Briza P, Nubauer A, Stolz F, Wallner M, Ferreira F. Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity. J Allergy Clin Immunol 2017 (epub ahead of print). doi: 10.1016/j.jaci.2017.10.027.

Schülke S, Kuttich K, Wolfheimer S, Duschek N, Wangorsch A, Reuter A, Briza P, Pablos I, Gadermaier G, Ferreira F, Vieths S, Toda M, Scheurer S. Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo. Scientific Rep 2017, 7:11782. doi: 10.1038/s41598-017-11972-w

Zulehner N, Nagl B, Briza P, Roulias A, Ballmer-Weber B, Zlabinger GJ, Ferreira F, Bohle B. Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot. Allergy 2017, 72: 244-51. 10.1111/all.12938

Wolf M, Twaroch TE, Huber S, Reithofer M, Steiner M, Aglas L, Hauser M, Aloisi I, Asam C, Hofer H, Parigiani MA, Ebner C, Bohle B, Briza P, Neubauer A, Stolz F, Jahn-Schmid B, Wallner M, Ferreira F. Amb a 1 isoforms: Unequal siblings with distinct immunological features. Allergy 2017, 10.1111/all.1319610.1111/all.13196

Stemeseder T, Freier R, Wildner S, Fuchs JE, Briza P, Lang R, Batanero E, Lidholm J, Liedl KR, Campo P, Hawranek T, Villalba M, Brandstetter H, Ferreira F, Gadermaier G. Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family. J Allergy Clin Immunol 2017, 140: 277-80. 10.1016/j.jaci.2016.10.035

Santos da Silva E, Asam C, Lackner P, Hofer H, Wallner M, Silva Pinheiro C, Alcantara-Neves NM, Ferreira F. Allergens of Blomia tropicalis: An Overview of Recombinant Molecules. Int Arch Allergy Immunol 2017, 172: 203-14. 10.1159/000464325

Soh WT, Briza P, Dall E, Asam C, Schubert M, Huber S, Aglas L, Bohle B, Ferreira F, Brandstetter H. Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci. 2017, pii:E2156. doi: 10.3390/ijms18102156

Sancho AI, Wallner M, Hauser M, Nagl B, Himly M, Asam C, Ebner C, Jahn-Schmid B, Bohle B, Ferreira F. T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice. PLoS One 2017, 12: e0169784. 10.1371/journal.pone.0169784

Pablos I, Eichhorn S, Briza P, Asam C, Gartner U, Wolf M, Ebner C, Bohle B, Arora N, Vieths S, Ferreira F, Gadermaier G. Proteomic profiling of the weed feverfew, a neglected pollen allergen source. Sci Rep 2017, 7: 6049. 10.1038/s41598-017-06213-z

McKenna OE, Posselt G, Briza P, Lackner P, Schmitt AO, Gadermaier G, Wessler S, Ferreira F. Multi-Approach Analysis for the Identification of Proteases within Birch Pollen. Int J Mol Sci 2017, 1810.3390/ijms18071433

Hollbacher B, Schmitt AO, Hofer H, Ferreira F, Lackner P. Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen. Int J Mol Sci 2017, 1810.3390/ijms18061199

Hofer H, Asam C, Hauser M, Nagl B, Laimer J, Himly M, Briza P, Ebner C, Lang R, Hawranek T, Bohle B, Lackner P, Ferreira F, Wallner M. Tackling Bet v 1 and associated food allergies with a single hybrid protein. J Allergy Clin Immunol 2017, 140: 525-33 e10. 10.1016/j.jaci.2016.09.055 16.

Hirschl S, Ralser C, Asam C, Gangitano A, Huber S, Ebner C, Bohle B, Wolf M, Briza P, Ferreira F, Griesbeck C, Wallner M. Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii. Int Arch Allergy Immunol 2017, 173: 44-50. 10.1159/000471852 17.

Ahammer L, Grutsch S, Wallner M, Ferreira F, Tollinger M. NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1. Biomol NMR Assign 11: 231-234, 2017, doi: 10.1007/s12104-017-9754-7.

Wildner S, Elsässer B, Stemeseder T, Briza P, Soh WT, Villalba M, Lidholm J, Brandstetter H, Gadermaier G. Endolysosomal Degradation of Allergenic Ole e 1-Like Proteins: Analysis of Proteolytic Cleavage Sites Revealing T Cell Epitope-Containing Peptides  Int J Mol Sci. 2017 Aug 16;18(8). pii: E1780.

Stemeseder T, Klinglmayr E, Moser S, Lang R, Himly M, Oostingh GJ, Zumbach J, Bathke AC, Hawranek T, Gadermaier G. Influence of intrinsic and lifestyle factors on the development of IgE sensitization. Int Arch Allergy Immunol. 2017;173(2):99-104.

Stemeseder T, Schweidler B, Doppler P, Klinglmayr E, Moser S, Lueftenegger L, Himly M, Lang R, Zumbach J, Oostingh GJ, Hawranek T, Bathke AC, Gadermaier G. Exposure to Indoor Allergens in Different Residential Settings and Its Influence on IgE Sensitization in a Geographically Confined Austrian Cohort.  PLoS One. 2017 Jan 3;12(1):e0168686.

Stemeseder T, Klinglmayr E, Moser S, Lueftenegger L, Lang R, Himly M, Oostingh G, Zumbach J, Bathke A, Hawranek T, Gadermaier G. Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.  Allergy. 2017 May;72(5):754-763.

 

2016

 

Steiner M, Hawranek T, Schneider M, Ferreira F, Horejs-Hoeck J, Harrer A, Himly M. Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels. PLoS One 2016, 11: e0149275. 10.1371/journal.pone.0149275

Silva ES, Pinheiro CS, Quintella CM, Ferreira F, LG CP, Alcantara-Neves NM. Advances in patent applications related to allergen immunotherapy. Expert Opin Ther Pat 2016, 26: 657-68. 10.1517/13543776.2016.1170809 20.

Moraes AH, Asam C, Batista A, Almeida FC, Wallner M, Ferreira F, Valente AP. 1H, 13C and 15N resonance assignments and second structure information of Fag s 1: Fagales allergen from Fagus sylvatica. Biomol NMR Assign 2016, 10: 45-8. 10.1007/s12104-015-9634-y

McKenna OE, Asam C, Araujo GR, Roulias A, Goulart LR, Ferreira F. How relevant is panallergen sensitization in the development of allergies? Pediatr Allergy Immunol 2016, 27: 560-8. 10.1111/pai.12589

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilo MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, PA EI, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Makela M, Morisset M, Niederberger V, Nowak-Wegrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol 2016, 27 Suppl 23: 1-250. 10.1111/pai.12563

Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. J Allergy Clin Immunol 2016, 137: 1525-34. 10.1016/j.jaci.2015.09.026

Himly M, Nandy A, Kahlert H, Thilker M, Steiner M, Briza P, Neubauer A, Klysner S, van Ree R, Buchheit KH, Vieths S, Ferreira F. Standardization of allergen products: 2. Detailed characterization of GMP-produced recombinant Phl p 5.0109 as European Pharmacopoeia reference standard. Allergy 2016, 71: 495-504. 10.1111/all.12824

Goodman RE, Ebisawa M, Ferreira F, Sampson HA, van Ree R, Vieths S, Baumert JL, Bohle B, Lalithambika S, Wise J, Taylor SL. AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity. Mol Nutr Food Res 2016, 60: 1183-98. 10.1002/mnfr.201500769

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 2016, 167: 1067-78 e16. 10.1016/j.cell.2016.09.050

Abfalter CM, Schonauer E, Ponnuraj K, Huemer M, Gadermaier G, Regl C, Briza P, Ferreira F, Huber CG, Brandstetter H, Posselt G, Wessler S. Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579. PLoS One 2016, 11: e0162433. 10.1371/journal.pone.0162433

Pablos I, Wildner S, Asam C, Wallner M, Gadermaier G. Pollen Allergens for Molecular Diagnosis Curr Allergy Asthma Rep. 2016 Apr;16(4):31. doi: 10.1007/s11882-016-0603-z. Review.

 

2015

 

Himly M, Nandy A, Kahlert H, Thilker M, Steiner M, Briza P, Angela N, Klysner S, van Ree R, Buchheit KH, Vieths S, Ferreira F. Standardization of allergen products: 2. Detailed characterization of GMP-produced recombinant Phl p 5.0109 as European Pharmacopoeia reference standard. Allergy. 2015 Dec 20. doi: 10.1111/all.12824. [Epub ahead of print] IF 6.028

Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. J Allergy Clin Immunol. 2015 Nov 11. pii: S0091-6749(15)01366-4. doi: 10.1016/j.jaci.2015.09.026. [Epub ahead of print] IF 11.476

Wimmer M, Alessandrini F, Gilles S, Frank U, Oeder S, Hauser M, Ring J, Ferreira F, Ernst D, Winkler JB, Schmitt-Kopplin P, Ohnmacht C, Behrendt H, Schmidt-Weber C, Traidl-Hoffmann C, Gutermuth J. Pollen-derived adenosine is a necessary cofactor for ragweed allergy. Allergy 2015, 70: 944-54. 10.1111/all.12642

Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F. Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern. PLoS One 2015, 10: e0120038. 10.1371/journal.pone.0120038

Oeder, S., Alessandrini, F., Wirz, O.F., Braun, A., Wimmer, M., Frank, U., Hauser, M., Durner, J., Ferreira, F., Ernst, D., Mempel, M., Gilles, S., Buters, J.T.M., Behrendt, H., Traidl-Hoffmann, C., Schmidt-Weber, C., Akdis, M., Gutermuth, J. Pollen-derived non-allergenic substances enhance Th2-induced IgE production in B cells. Allergy (Nov 2015). doi: 10.1111/all.12707 (epub ahead of print). IF 6.028

Wimmer, M., Alessandrini, F., Gilles, S., Frank, U., Oeder, S., Hauser, M., Ring, J., Ferreira, F., Ernst, D., Winkler, J.B., Schmitt-Kopplin, P., Ohnmacht, C., Behrendt, H., Schmidt-Weber, C., Traidl-Hoffmann, C., Gutermuth, J. Pollen-derived adenosine is a necessary co-factor for ragweed allergy. Allergy (Aug 2015) 70:944-954. doi: 10.1111/all.12642 IF 6.028

Moraes AH, Asam C, Batista A, Almeida FC, Wallner M, Ferreira F, Valente AP. 1H, 13C and 15N resonance assignments and second structure information of Fag s 1: Fagales allergen from Fagus sylvatica. Biomol NMR Assign. 2015 Aug 20. IF 0.760

Kitzmüller C., Zulehner, N., Roulias, A., Briza, P., Ferreira, F., Faé, I., Fischer, G.F., Bohle, B. Correlation of sensitization capacity and T-cell recognition within the Bet v 1 family. J. Allergy Clin. Immunol. (Jul 2015) 136:151-158. doi: 10.1016/j.jaci.2014.12.1928 IF 11.476

Asam C, Hofer H, Wolf M, Aglas L, Wallner M. Tree pollen allergens-an update from a molecular perspective.  Allergy. 2015 Jul 17. doi: 10.1111/all.12696. IF 6.028

Pichler, U., Hauser, M., Wolf, M., Bernardi, M.L., Gadermaier, G., Weiss, R., Ebner, C., Yokoi, H., Takai, T., Didierlaurent, D., Rafaiani, C., Briza, P., Mari, A., Behrendt, H., Wallner, M., Ferreira, F. Pectate lyase allergens: sensitization profiles and cross-reactivity pattern. Plos One (May 2015) 10(5): e0120038. doi: 10.1371/journal.pone.0120038. IF 3.234

Laimer J, Hofer H, Fritz M, Wegenkittl S, Lackner P. MAESTRO--multi agent stability prediction upon point mutations. BMC Bioinformatics. 2015 Apr 16;16:116. doi: 10.1186/s12859-015-0548-6. IF 2.576

Dall E, Fegg JC, Briza P, Brandstetter H. Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain. Angew Chem Int Ed Engl. 2015 Mar 2;54(10):2917-21. doi: 10.1002/anie.201409135. IF 11.261

 

2014

 

Kofler, S., Ackaert, C., Samonig, M., Asam, C., Briza, P., Horejs-Hoeck, J., Cabrele, C., Ferreira, F., Duschl, A., Huber, C., Brandstetter, H. Stabilization of the dimerich birch pollen allergen Bet v 1 impacts its immunological properties. J. Biol. Chem. (2014) 289:540-551, doi: 10.1074/jbc.M113.518795

Radauer, C., Nandy, A., Ferreira, F., Goodman, R.E., Larsen, J.N., Lidholm, J., Pomes, A., Raulf-Heimsoth, M., Rozynek, P., Thomas, W.R., Breiteneder, H. Update of the WHO/IUIS Allergen Nomenclarutre Database based on analysis of allergen sequences. Allergy (2014) 69:413-419. doi: 10.1111/all.12348

Gadermaier, G., Eichhorn, S., Vejvar, E. Weilnböck, L., Lang, R., Briza, P., Huber, C.G., Ferreira, F., Hawranek, T. Plantago lanceolata: an important trigger of summer pollinosis with limited IgE cross-reactivity. J. Allergy Clin. Immunol. (2014) 134:472-475. doi: 10.1016/j.jaci.2014.02.016

Asam, C., Batista, A.L., Moraes, A.H. de Paula, V.S., Almeida, F.C.L., Aglas, L., Kitzmüller, C., Bohle, B., Ebner, C., Ferreira, F., Wallner, M., Valente, A.P. Bet v 1 – a Trojan horse for small ligands boosting allergic sensitization? Clin Exp Allergy (2014) 44: 1083-93. doi: 10.1111/cea.12361

Ferreira, F., Wolf, M., Wallner, M. Molecular approach to allergy diagnosis and therapy.Yonsei Med J (2014) 55: 839-852. doi: 10.3349/ymj.2014.55.4.839

Grutsch, S., Fuchs, J.F., Fischer, R., Kofler, S., Bibi, M., Asam, C., Wallner, M., Ferreira, F., Brandstetter, H., Liedl, K.R., Tollinger, M. Ligand binding modulates structural dynamics and compactness of the major birch pollen allergen. Biophys. J. (2014) 107: 2963-72. doi: 10.1016/j.bpj.2014.10.062

Moraes, A.H., Ackerbauer, D., Kostadinova, M., Bublin, M., de Oliveira, G.A., Ferreira, F., Almeida, F.C., Breiteneder, H., Valente, A.P. Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. Proteins (2014) 82: 3032-42. doi: 10.1002/prot.24664

Delfi, S., Zwicker, C., Vejvar, E., Kitzmüller, C., Gadermaier, G., Nagl, B., Vrtala, S., Briza, P., Zlabinger, G.J., Jahn-Schmid, B., Ferreira, F., Bohle, B. Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen. Plos One (2014) 9(9):e109075. doi: 10.1371/journal.pone.0109075

Ackaert, C., Kofler, S., Horejs-Höck, J., Zulehner, N., Asam, C., von Grafenstein, S., Fuchs, J.E., Briza, P., Liedl, K.R., Bohle, B., Ferreira, F., Brandstetter, H., Oostingh, G.J., Duschl, A. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. Plos One (2014) e104520. doi: 10.1371/journal.pone.0104520

Roulias, A., Pichler, U., Hauser, M., Himly, M., Hofer, H., Lackner, P., Ebner, C., Briza, P., Bohle, B., Egger, M., Wallner, M., Ferreira, F. Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis. 2014 Feb;69(2):208-15. Epub 2013 Nov 14.doi: 10.1111/all.12306.

Pichler, U., Hauser, M., Hofer, H., Himly, M., Hoflehner, E., Steiner, M., Mutschlechner, S., Hufnagl, K., Ebner, C., Mari, A., Briza, P., Bohle, B., Wiedermann, U., Ferreira, F., Wallner, M. Allergen hybrids – next generation vaccines for Fagales pollen immunotherapy. Clin Exp Allergy. 2014 Mar;44(3):438-49. doi: 10.1111/cea.12250.

Hofbauer SW, Krenn PW, Ganghammer S, Asslaber D, Pichler U, Oberascher K, Henschler R, Wallner M, Kerschbaum H, Greil R, Hartmann TN. Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells. Blood. 2014 Apr 3;123(14):2181-8. doi: 10.1182/blood-2013-08-523563.

Deressa T, Stoecklinger A, Wallner M, Himly M, Kofler S, Hainz K, Brandstetter H, Thalhamer J, Hammerl P. Structural Integrity of the Antigen Is a Determinant for the Induction of T-Helper Type-1 Immunity in Mice by Gene Gun Vaccines against E.coli Beta-Galactosidase. PLoS One. 2014 Jul 15;9(7):e102280. doi: 10.1371/journal.pone.0102280.

Gadermaier G. Non-specific lipid transfer proteins: a protein family in search of an allergenic pattern. Int Arch Allergy Immunol. 2014;164(3):169-70. doi: 10.1159/000364824.

Reinmuth-Selzle K, Ackaert C, Kampf CJ, Samonig M, Shiraiwa M, Kofler S, Yang H, Gadermaier G, Brandstetter H, Huber CG, Duschl A, Oostingh GJ, Pöschl U. Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.J Proteome Res. 2014 Mar 7;13(3):1570-7. doi: 10.1021/pr401078h.

Schülke S, Wolfheimer S, Gadermaier G, Wangorsch A, Siebeneicher S, Briza P, Spreitzer I, Schiller D, Loeschner B, Uematsu S, Ryffel B, Akira S, Waibler Z, Vieths S, Toda M, Scheurer S. Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC. PLoS One. 2014 Feb 7;9(2):e87822. doi: 10.1371/journal.pone.0087822.

Heilmann M, Wellner A, Gadermaier G, Ilchmann A, Briza P, Krause M, Nagai R, Burgdorf S, Scheurer S, Vieths S, Henle T, Toda M. Ovalbumin modified with pyrraline, a Maillard reaction product, shows enhanced T-cell immunogenicity. J Biol Chem. 2014 Mar 14;289(11):7919-28. doi: 10.1074/jbc.M113.523621.

Zuidmeer-Jongejan L, Fernández-Rivas M, Winter MG, Akkerdaas JH, Summers C, Lebens A, Knulst AC, Schilte P, Briza P, Gadermaier G, van Ree R. Oil body-associated hazelnut allergens including oleosins are underrepresented in diagnostic extracts but associated with severe symptoms. Clin Transl Allergy. 2014 Feb 2;4(1):4. doi: 10.1186/2045-7022-4-4.

Stemeseder T, Hemmer W, Hawranek T, Gadermaier G. Marker allergens of weed pollen - basic considerations and diagnostic benefits in the clinical routine: Part 16 of the Series Molecular Allergology. Allergo J Int. 2014;23(8):274-280. Epub 2014 Dec 23. Review.      

 

2013


Wallner M, Pichler U, Ferreira F. Recombinant allergens for pollen immunotherapy. Immunotherapy. 2013 Dec;5(12):1323-38. doi: 10.2217/imt.13.114.

Roulias A, Pichler U, Hauser M, Himly M, Hofer H, Lackner P, Ebner C, Briza P, Bohle B, Egger M, Wallner M, Ferreira F. Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis. Allergy. 2014 Feb;69(2):208-15. doi: 10.1111/all.12306. Epub 2013 Nov 14.

Acevedo N, Mohr J, Zakzuk J, Samonig M, Briza P, Erler A, Pomés A, Huber CG, Ferreira F, Caraballo L. Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. PLoS One. 2013 Nov 4;8(11):e78353. doi: 10.1371/journal.pone.0078353. eCollection 2013.

Pichler U, Asam C, Weiss R, Isakovic A, Hauser M, Briza P, Ferreira F, Wallner M. The fold variant BM4 is beneficial in a therapeutic Bet v 1 mouse model. Biomed Res Int. 2013;2013:832404. doi: 10.1155/2013/832404. Epub 2013 Sep 23.

Vejvar E, Himly M, Briza P, Eichhorn S, Ebner C, Hemmer W, Ferreira F, Gadermaier G. Allergenic relevance of nonspecific lipid transfer proteins 2: Identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family. Mol Nutr Food Res. 2013 Nov;57(11):2061-70. doi: 10.1002/mnfr.201300085. Epub 2013 Aug 5.

Gadermaier G, Hauser M, Ferreira F. Allergens of weed pollen: An overview on recombinant and natural molecules. Methods. 2014 Mar 1;66(1):55-66. doi: 10.1016/j.ymeth.2013.06.014. Epub 2013 Jun 24. Review.

Santos KS, Gadermaier G, Vejvar E, Arcuri HA, Galvão CE, Yang AC, Resende VM, Martins Cde O, Himly M, Mari A, Liso M, Pomponi D, Breiteneder H, Wagner S, Kalil J, Ferreira F, Castro FF. Novel allergens from ancient foods: Man e 5 from manioc (Manihot esculenta Crantz) cross reacts with Hev b 5 from latex. Mol Nutr Food Res. 2013 Jun;57(6):1100-9. doi: 10.1002/mnfr.201200433. Epub 2013 Mar 25.

Schulten V, Greenbaum JA, Hauser M, McKinney DM, Sidney J, Kolla R, Lindestam Arlehamn CS, Oseroff C, Alam R, Broide DH, Ferreira F, Grey HM, Sette A, Peters B. Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3459-64. doi: 10.1073/pnas.1300512110. Epub 2013 Feb 11. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5269. Ferreira-Briza, Fatima [corrected to Ferreira, Fatima]. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8750.

Gao ZS, Yang ZW, Wu SD, Wang HY, Liu ML, Mao WL, Wang J, Gadermaier G, Ferreira F, Zheng M, van Ree R. Peach allergy in China: a dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. J Allergy Clin Immunol. 2013 Jan;131(1):224-6.e1-3. doi: 10.1016/j.jaci.2012.07.015. Epub 2012 Aug 30. No abstract available.

Kanter U, Heller W, Durner J, Winkler JB, Engel M, Behrendt H, Holzinger A, Braun P, Hauser M, Ferreira F, Mayer K, Pfeifer M, Ernst D. Molecular and immunological characterization of ragweed (Ambrosia artemisiifolia L.) pollen after exposure of the plants to elevated ozone over a whole growing season. PLoS One. 2013 Apr 18;8(4):e61518. doi: 10.1371/journal.pone.0061518. Print 2013.

Weinberger EE, Himly M, Myschik J, Hauser M, Altmann F, Isakovic A, Scheiblhofer S, Thalhamer J, Weiss R. Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: a novel tool for specific immunotherapy. J Control Release. 2013 Jan 28;165(2):101-9. doi: 10.1016/j.jconrel.2012.11.002. Epub 2012 Nov 10.

 

2012

 

Arshad SH, Dharmage SC, Ferreira F, Fixman ED, Gadermaier G, Hauser M, Sampson AP, Teran LM, Wallner M, Wardlaw AJ. Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy. Clin Exp Allergy. 2012 Dec;42(12):1697-723. doi: 10.1111/cea.12037. Review.

Kitzmüller C, Wallner M, Deifl S, Mutschlechner S, Walterskirchen C, Zlabinger GJ, Ferreira F, Bohle B. A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T-cell activation. Allergy. 2012 Nov;67(11):1375-82. doi: 10.1111/all.12016. Epub 2012 Sep 13.

Golias J, Schwarzer M, Wallner M, Kverka M, Kozakova H, Srutkova D, Klimesova K, Sotkovsky P, Palova-Jelinkova L, Ferreira F, Tuckova L. Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. PLoS One. 2012;7(5):e37156. doi: 10.1371/journal.pone.0037156. Epub 2012 May 21. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/53227638-162d-477c-a487-ad856854d823.

Karle AC, Oostingh GJ, Mutschlechner S, Ferreira F, Lackner P, Bohle B, Fischer GF, Vogt AB, Duschl A. Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells. PLoS One. 2012;7(2):e31483. doi: 10.1371/journal.pone.0031483. Epub 2012 Feb 14.

Filep S, Tsay A, Vailes LD, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard. J Allergy Clin Immunol. 2012 May;129(5):1408-10. doi: 10.1016/j.jaci.2011.12.978. Epub 2012 Jan 24. No abstract available.

Jahn-Schmid B, Hauser M, Wopfner N, Briza P, Berger UE, Asero R, Ebner C, Ferreira F, Bohle B. Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. J Immunol. 2012 Feb 1;188(3):1559-67. doi: 10.4049/jimmunol.1102445. Epub 2011 Dec 28.

Siegert M, Pertl-Obermeyer H, Gadermaier G, Ferreira F, Obermeyer G. Expression of the major mugwort pollen allergen Art v 1 in tobacco plants and cell cultures: problems and perspectives for allergen production in plants. Plant Cell Rep. 2012 Mar;31(3):561-71. doi: 10.1007/s00299-011-1199-3. Epub 2011 Dec 13.

Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy. 2012 Feb;67(2):235-41. doi: 10.1111/j.1398-9995.2011.02750.x. Epub 2011 Nov 18.

Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H. Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen Bet v 1. J Mol Biol. 2012 Sep 7;422(1):109-23. doi: 10.1016/j.jmb.2012.05.016. Epub 2012 May 23.

Zaborsky N, Brunner M, Wallner M, Himly M, Karl T, Schwarzenbacher R, Ferreira F, Achatz G. Response to Detection and analysis of unusual features in the structural model and structure-factor data of a birch pollen allergen. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):377. doi: 10.1107/S1744309112008433. Epub 2012 Mar 31.

Hoy B, Geppert T, Boehm M, Reisen F, Plattner P, Gadermaier G, Sewald N, Ferreira F, Briza P, Schneider G, Backert S, Wessler S. Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin. J Biol Chem. 2012 Mar 23;287(13):10115-20. doi: 10.1074/jbc.C111.333419. Epub 2012 Feb 15.

 

2011

 

Hauser M, Asam C, Himly M, Palazzo P, Voltolini S, Montanari C, Briza P, Bernardi ML, Mari A, Ferreira F, Wallner M.Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals. Clin Exp Allergy. 2011 Dec;41(12):1804-14.


Gadermaier G, Hauser M, Egger M, Ferrara R, Briza P, Santos KS, Zennaro D, Girbl T, Zuidmeer-Jongejan L, Mari A, Ferreira F. Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PLoS One. 2011;6(8):e24150. Epub 2011 Aug 29. 


Santos KS, Galvao CE, Gadermaier G, Resende VM, de Oliveira Martins C, Misumi DS, Yang AC, Ferreira F, Palma MS, Kalil J, Castro FF. 
Allergic reactions to manioc (Manihot esculenta Crantz): identification of novel allergens with potential involvement in latex-fruit syndrome.
J Allergy Clin Immunol. 2011 Dec;128(6):1367-9.

Pasqualini S, Tedeschini E, Frenguelli G, Wopfner N, Ferreira F, D´Amato G, Ederli L. Ozone affects pollen viability and NAD(P)H oxidase release from Ambrosia artemisiifolia pollen.
Environ Pollut. 2011 Oct;159(10):2823-30.

Egger M, Alessandri C, Wallner M, Briza P, Zennaro D, Mari A, Ferreira F, Gadermaier G. Is aboriginal food less allergenic? Comparing IgE-reactivity of eggs from modern and ancient chicken breeds in a cohort of allergic children.
PLoS One. 2011 Apr 28;6(4):e19062.

Gadermaier G, Egger M, Girbl T, Erler A, Harrer A, Vejvar E, Liso M, Richter K, Zuidmeer L, Mari A, Ferreira F. Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks.
Mol Nutr Food Res. 2011 Apr;55(4):568-77.

Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A, Asam C, Pichler U, van Ree R, Briza P, Thalhamer J, Bohle B, Achatz G, Ferreira F. Reshaping the Bet v 1 fold modulates T(H) polarization.
J Allergy Clin Immunol. 2011 Jun;127(6):1571-8.e9.

Erler A, Hawranek T, Krückemeier L, Asam C, Egger M, Ferreira F, Briza P. Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins.
Proteomics. 2011 Apr;11(8):1486-98.

Egger M, Jürets A, Wallner M, Briza P, Ruzek S, Hainzl S, Pichler U, Kitzmüller C, Bohle B, Huber CG, Ferreira F. Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome.
PLoS One. 2011 Feb 16;6(2):e17278.

Schulten V, Nagl B, Scala E, Bernardi ML, Mari A, Ciardiello MA, Lauer I, Scheurer S, Briza P, Jürets A, Ferreira F, Jahn-Schmid B, Fischer GF, Bohle B. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy. 2011 Aug;66(8):1005-13.

D´Avino R, Bernardi ML, Wallner M, Palazzo P, Camardella L, Tuppo L, Alessandri C, Breiteneder H, Ferreira F, Ciardiello MA, Mari A.
Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen. Allergy. 2011 Jul;66(7):870-7.

Aiub CA, Gadermaier G, Silva IO, Felzenszwalb I, Pinto LF, Ferreira F, Eckl P. N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes. Genet Mol Res. 2011 Oct 5;10(4):2340-8.

Aiub CA, Gadermaier G, Oliveira I, Felzenszwalb I, Ferreira F, Ribeiro Pinto LF, Eckl P. N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. Toxicol Lett. 2011 Oct 10;206(2):139-43.

 

2010

Gadermaier G, Egger M, Girbl T, Erler A, Harrer A, Vejvar E, Liso M, Richter K, Zuidmeer L, Mari A, Ferreira F. Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks.
Mol Nutr Food Res. 2010 Dec 20.

Zaborsky N, Brunner M, Wallner M, Himly M, Karl T, Schwarzenbacher R, Ferreira F, Achatz G. Antigen aggregation decides the fate of the allergic immune response. J Immunol. 2010 Jan 15;184(2):725-35.

Harrer A, Lang R, Grims R, Braitsch M, Hawranek T, Aberer W, Vogel L, Schmid W, Ferreira F, Himly M. Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites. PLoS One. 2010 Oct 28;5(10):e13707.

Acevedo N, Erler A, Briza P, Puccio F, Ferreira F, Caraballo L.
Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int Arch Allergy Immunol. 2011;154(3):195-206. Epub 2010 Sep 21.

Weiss R, Scheiblhofer S, Roesler E, Ferreira F, Thalhamer J.
Prophylactic mRNA vaccination against allergy. Curr Opin Allergy Clin Immunol. 2010 Dec;10(6):567-74.

Razzera G, Gadermaier G, de Paula V, Almeida MS, Egger M, Jahn-Schmid B, Almeida FC, Ferreira F, Valente AP.
Mapping the interactions between a major pollen allergen and human IgE antibodies. Structure. 2010 Aug 11;18(8):1011-21.

Jahn-Schmid B, Wopfner N, Hubinger G, Asero R, Ebner C, Ferreira F, Bohle B. The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements. J Allergy Clin Immunol. 2010 Nov;126(5):1068-71, 1071.e1-2.

Egger M, Hauser M, Mari A, Ferreira F, Gadermaier G.
The role of lipid transfer proteins in allergic diseases. Curr Allergy Asthma Rep. 2010 Sep;10(5):326-35. Review.

Léonard R, Wopfner N, Pabst M, Stadlmann J, Petersen BO, Duus JØ, Himly M, Radauer C, Gadermaier G, Razzazi-Fazeli E, Ferreira F, Altmann F. A new allergen from ragweed (Ambrosia artemisiifolia) with homology to art v 1 from mugwort.  Biol Chem. 2010 Aug 27;285(35):27192-200. 


Magler I, Nüss D, Hauser M, Ferreira F, Brandstetter H.
Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping.  FEBS  2010 Jun;277(12):2598-610.

Thalhamer T, Dobias H, Stepanoska T, Pröll M, Stutz H, Dissertori O, Lackner P, Ferreira F, Wallner M, Thalhamer J, Hartl A. Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening. Allergy Clin Immunol. 2010 Apr;125(4):926-934.e10.

Hauser M, Roulias A, Ferreira F, Egger M. Panallergens and their impact on the allergic patient.  Allergy Asthma Clin Immunol. 2010 Jan 18;6(1):1.

Valenta R, Ferreira F, Focke-Tejkl M, Linhart B, Niederberger V, Swoboda I, Vrtala S.
From allergen genes to allergy vaccines. Annu Rev Immunol. 2010 Mar;28:211-41. Review.

Mutschlechner S, Egger M, Briza P, Wallner M, Lackner P, Karle A, Vogt AB, Fischer GF, Bohle B, Ferreira F. Naturally processed T cell-activating peptides of the major birch pollen allergen. J Allergy Clin Immunol. 2010 Mar;125(3):711-8, 718.e1-718.e2.

Gadermaier G, Jahn-Schmid B, Vogel L, Egger M, Himly M, Briza P, Ebner C, Vieths S, Bohle B, Ferreira F. Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy.
Mol Immunol. 2010 Mar;47(6):1292-8.

Smole U, Balazs N, Hoffmann-Sommergruber K, Radauer C, Hafner C, Wallner M, Ferreira F, Grössinger R, de Jong EC, Wagner S, Breiteneder H. Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001.
Immunobiology. 2010 Nov;215(11):903-9.

Harrer A, Egger M, Gadermaier G, Erler A, Hauser M, Ferreira F, Himly M. Characterization of plant food allergens: an overview on physicochemical and immunological techniques.
Mol Nutr Food Res. 2010 Jan;54(1):93-112. Review.

 

2009


Roesler E, Weiss R, Weinberger EE, Fruehwirth A, Stoecklinger A, Mostböck S, Ferreira F, Thalhamer J, Scheiblhofer S. Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens. J Allergy Clin Immunol. 2009 Nov;124(5):1070-7.e1-11.

Egger M, Hauser M, Himly M, Wopfner N, Wallner M, Ferreira F. Development of recombinant allergens for diagnosis and therapy. Front Biosci (Elite Ed). 2009 Jun 1;1:77-90.

Gadermaier G, Harrer A, Girbl T, Palazzo P, Himly M, Vogel L, Briza P, Mari A, Ferreira F. Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen. Mol Immunol. 2009 Jun;46(10):1919-24.

Gruber P, Gadermaier G, Bauer R, Weiss R, Wagner S, Leonard R, Breiteneder H, Ebner C, Ferreira F, Egger M. Role of the polypeptide backbone and post-translational modifications in cross-reactivity of Art v 1, the major mugwort pollen allergen. Biol Chem. 2009 May-Jun;390(5-6):445-51.

Wopfner N, Jahn-Schmid B, Schmidt G, Christ T, Hubinger G, Briza P, Bohle B, Vogel L, Ebner C, Asero R, Ferreira F, Schwarzenbacher R. The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level. Mol Immunol. 2009 Mar 5.

Himly M, Nony E, Chabre H, Van Overtvelt L, Neubauer A, van Ree R, Buchheit KH, Vieths S, Moingeon P, Ferreira F. Standardization of allergen products: 1. Detailed characterization of GMP-produced recombinant Bet v 1.0101 as biological reference preparation. Allergy. 2009 Jan 29.

Wallner M, Erler A, Hauser M, Klinglmayr E, Gadermaier G, Vogel L, Mari A, Bohle B, Briza P, Ferreira F. Immunologic characterization of isoforms of Car b 1 and Que a 1, the major hornbeam and oak pollen allergens.
Allergy. 2009 Mar;64(3):452-60. Epub 2009 Jan 17.

Klinglmayr E, Hauser M, Zimmermann F, Dissertori O, Lackner P, Wopfner N, Ferreira F, Wallner M.
Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens. Array-based profiling of ragweed and mugwort pollen allergens.  Allergy. 2009 Jan 9.

Dedic A, Gadermaier G, Vogel L, Ebner C, Vieths S, Ferreira F, Egger M. Immune recognition of novel isoforms and domains of the mugwort pollen major allergen Art v 1. Array-based profiling of ragweed and mugwort pollen allergens.
Mol Immunol. 2009 Jan;46(3):416-21. Epub 2008 Dec 2.

 

2008

Gadermaier G, Wopfner N, Wallner M, Egger M, Didierlaurent A, Regl G, Aberger F, Lang R, Ferreira F, Hawranek T. Array-based profiling of ragweed and mugwort pollen allergens.  Allergy. 2008 Nov;63(11):1543-9.

Mohapatra SS, San-Juan-Vergara H, Wopfner N, Ferreira F. Experimental forms of allergen immunotherapy with modified allergens and adjuvants.  Clin Allergy Immunol. 2008;21:393-413. Review.

Chapman MD, Ferreira F, Villalba M, Cromwell O, Bryan D, Becker WM, Fernández-Rivas M, Durham S, Vieths S, van Ree R. CREATE consortium. The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines. J Allergy Clin Immunol. 2008 Nov;122(5):882-889.e2.

Jahn-Schmid B, Sirven P, Leb V, Pickl WF, Fischer GF, Gadermaier G, Egger M, Ebner C, Ferreira F, Maillére B, Bohle B. Characterization of HLA class II/peptide-TCR interactions of the immunodominant T cell epitope in Art v 1, the major mugwort pollen allergen. J Immunol. 2008 Sep 1;181(5):3636-42.

Wopfner N, Gruber P, Wallner M, Briza P, Ebner C, Mari A, Richter K, Vogel L, Ferreira F.
Molecular and immunological characterization of novel weed pollen pan-allergens.  Allergy. 2008 Jul;63(7):872-81.

van Ree R, Chapman MD, Ferreira F, Vieths S, Bryan D, Cromwell O, Villalba M, Durham SR, Becker WM, Aalbers M, André C, Barber D, Cistero Bahima A, Custovic A, Didierlaurent A, Dolman C, Dorpema JW, Di Felice G, Eberhardt F, Fernandez Caldas E, Fernandez Rivas M, Fiebig H, Focke M, Fötisch K, Gadermaier G, Das RG, Gonzalez Mancebo E, Himly M, Kinaciyan T, Knulst AC, Kroon AM, Lepp U, Marco FM, Mari A, Moingeon P, Monsalve R, Neubauer A, Notten S, Ooievaar-de Heer P, Pauli G, Pini C, Purohit A, Quiralte J, Rak S, Raulf-Heimsoth M, San Miguel Moncin MM, Simpson B, Tsay A, Vailes L, Wallner M, Weber B. The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy. 2008 Mar;63(3):310-26. Review.

Wopfner N, Bauer R, Thalhamer J, Ferreira F, Chapman M.Immunologic analysis of monoclonal and immunoglobulin E antibody epitopes on natural and recombinant Amb a 1. Clin Exp Allergy. 2008 Jan;38(1):219-26.

Oberhuber C, Ma Y, Wopfner N, Gadermaier G, Dedic A, Niggemann B, Maderegger B, Gruber P, Ferreira F, Scheiner O, Hoffmann-Sommergruber K. Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients. Int Arch Allergy Immunol. 2008;145(2):94-101.

 

2007

Westritschnig K, Linhart B, Focke-Tejkl M, Pavkov T, Keller W, Ball T, Mari A, Hartl A, Stöcklinger A, Scheiblhofer S, Thalhamer J, Ferreira F, Vieths S, Vogel L, Böhm A, Valent P, Valenta R. A hypoallergenic vaccine obtained by tail-to-head restructuring of timothy grass pollen profilin, Phl p 12, for the treatment of cross-sensitization to profilin. J Immunol. 2007 Dec 1;179(11):7624-34.

Wallner M, Stöcklinger A, Thalhamer T, Bohle B, Vogel L, Briza P, Breiteneder H, Vieths S, Hartl A, Mari A, Ebner C, Lackner P, Hammerl P, Thalhamer J, Ferreira F.
Allergy multivaccines created by DNA shuffling of tree pollen allergens. J Allergy Clin Immunol. 2007 Aug;120(2):374-80.

Stoecklinger A, Grieshuber I, Scheiblhofer S, Weiss R, Ritter U, Kissenpfennig A, Malissen B, Romani N, Koch F, Ferreira F, Thalhamer J, Hammerl P.
Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization.
J Immunol. 2007 Jul 15;179(2):886-93.

Wallner M, Briza P, Thalhamer J, Ferreira F. Specific immunotherapy in pollen allergy. Curr Opin Mol Ther. 2007 Apr;9(2):160-7. Review.

Wopfner N, Dissertori O, Ferreira F, Lackner P.
Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin North Am. 2007 Feb;27(1):29-44. Review.

Chapman MD, Pomés A, Breiteneder H, Ferreira F.
Nomenclature and structural biology of allergens. J Allergy Clin Immunol. 2007 Feb;119(2):414-20. Review.

Wild C, Wallner M, Hufnagl K, Fuchs H, Hoffmann-Sommergruber K, Breiteneder H, Scheiner O, Ferreira F, Wiedermann U. A recombinant allergen chimer as novel mucosal vaccine candidate for prevention of multi-sensitivities.
Allergy. 2007 Jan;62(1):33-41.

 

2006

Mutschlechner S, Ferreira F. Engineering allergens.  Eur Ann Allergy Clin Immunol. 2006 Sep;38(7):226-9. Review.

Zuidmeer L, van Leeuwen WA, Kleine Budde I, Breiteneder H, Ma Y, Mills C, Sancho AI, Meulenbroek EJ, van de Weg E, Gilissen L, Ferreira F, Hoffmann-Sommergruber K, van Ree R. Allergenicity assessment of apple cultivars: hurdles in quantifying labile fruit allergens. Int Arch Allergy Immunol. 2006;141(3):230-40.

Ma Y, Zuidmeer L, Bohle B, Bolhaar ST, Gadermaier G, Gonzalez-Mancebo E, Fernandez-Rivas M, Knulst AC, Himly M, Asero R, Ebner C, van Ree R, Ferreira F, Breiteneder H, Hoffmann-Sommergruber K. Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy. 2006 Aug;36(8):1087-96.

Radauer, C., Willerroider, M., Fuchs, H., Hoffmann-Sommergruber, K., Thalhamer, J., Ferreira, F., Scheiner, O., Breiteneder, H. Cross-reactive and species-specific immunoglobuliin E epitopes of plant profilins: an experimental and structure-based analysis. Clin Exp Allergy. 2006 Jul;36(7):920-9.

Bauer R, Scheiblhofer S, Kern K, Gruber C, Stepanoska T, Thalhamer T, Hauser-Kronberger C, Alinger B, Zoegg T, Gabler M, Ferreira F, Hartl A, Thalhamer J, Weiss R. Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy.
J Allergy Clin Immunol. 2006 Jul;118(1):269-76.

Scheiblhofer S, Gabler M, Leitner WW, Bauer R, Zoegg T, Ferreira F, Thalhamer J, Weiss R. Inhibition of type I allergic responses with nanogram doses of replicon-based DNA vaccines. Allergy. 2006 Jul;61(7):828-35.

Asero R, Wopfner N, Gruber P, Gadermaier G, Ferreira F. Artemisia and Ambrosia hypersensitivity: co-sensitization or co-recognition? Clin Exp Allergy. 2006 May;36(5):658-65.

Ferreira F, Briza P, Inführ D, Schmidt G, Wallner M, Wopfner N, Thalhamer J, Achatz G. Modified recombinant allergens for safer immunotherapy. Inflamm Allergy Drug Targets. 2006 Jan;5(1):5-14. Review.

 

2005

Jahn-Schmid, B., Fischer, G., Bohle, B., Fae, I., Gadermaier, G., Dedic, A., Ferreira, F., Ebner, C. Antigen presentation of the immunodominant T cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1*01. J. Allergy Clin. Immunol. 115: 399-404, 2005

Leonard, R., Petersen, B.O., Himly, M., Kaar, W., Wopfner, N., Kolarich, D., van Ree, R., Ebner, C., Duus, J.Ø., Ferreira, F., Altmann, F. Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding.
J. Biol. Chem. 280:7932-7940, 2005

Hebenstreit, D., Ferreira, F. Structural changes in calcium-binding allergens: use of circular dichroism to study binding characteristics. Allergy 60: 1208-1211,2005

Bolhaar, S.T.H.P., Zuidmeer, L., Ma, Y., Ferreira, F., Bruijnzeel-Koomen, C.A.F.M., Hoffmann-Sommergruber, van Ree, R., Knulst, A.C. A mutant of the major apple allergen, Mal d 1 demonstrating hypo-allergenicity in target organ by DBPCFC. Clin. Exp. Allergy 35:1638-1644, 2005

Obermeyer, G., Ferreira, F. Can we predict or avoid the allergenic potential of genetically modified organisms? Int. Arch. Allergy Immunol. 137: 151-152, 2005

Wopfner, N., Gadermaier, G., Egger, M., Asero, R., Ebner, C., Jahn-Schmidt, B., Ferreira, F. The spectrum of allergens in ragweed and mugwort pollen.
Int. Arch. Allergy Immunol. 138:337-346, 2005

 

2004

Hartl., A., Hochreiter, R., Stepanoska, T., Ferreira, F., Thalhamer, J. Characterization of the protective and therapeutic efficiency of a DNA vaccine encoding the major birch pollen allergen Bet v 1a. Allergy 59: 65-73, 2004

Ferreira, F., Hawranek, T., Gruber, P., Wopfner, N., Mari, A. Allergic cross-reactivity: from gene to the clinic. Allergy 59: 243-267, 2004

Wallner, M., Gruber, P., Radauer, C., Maderegger, B., Susani, M., Hoffman-Sommergruber, K., Ferreira, F. Lab scale and medium production of recombinant allergens in Escherichia coli. Methods 32: 219-226, 2004

Obermeyer, G., Gehwolf, R., Sebesta, W., Hamilton, N., Gadermaier, G., Ferreira, F., Commandeur, U., Fisher, R., Bentrup, F.W. Over-expression and production of plant allergens by molecular farming strategies. Methods 32: 235-240, 2004

Ferreira, F., Wallner, M., Thalhamer, J.
Costumized antigens and immunomodulations for desensitizing allergic patients. Adv. Immunol. 84: 79-129, 2004

Neudecker, P., Nerkamp, J., Eisenmann, A., Nourse, A., Lauber, T., Schweimer, K., Lehmann, K., Ferreira, F., Rösch, P. Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function. J. Mol. Biol. 336:1141-57, 2004

Gadermaier, G., Dedic, A., Obermeyer, G., Frank, S., Himly, M., Ferreira, F. Biology of weed pollen allergens. Current Allergy and Asthma Rep. 4:391-400, 2004

 

2003

 

Markovic-Housley, Z., Degano, M., Lamba, D., von Roepenack-Lahaye, E., Clemens, S., Susani, M., Ferreira, F., Scheiner, O., Breiteneder, H. Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. J. Mol. Biol. 325: 123-133, 2003

Himly, M., Jahn-Schmid, B., Pittertschatscher, K., Bohle, B., Grubmayr, K., Ferreira, F., Ebner, H., Ebner, C. IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. J. Allergy Clin. Immunol. 111: 882-8, 2003

Schmid-Grendelmeier, P., Holzmann,D., Himly, M., Weichel, M., Tresch, S., Ruckert, B., Menz, G., Ferreira, F., Blaser, K., Wüthrich, B., Crameri, R. Native and recombinant Art v 1 are able to induce humoral and T cell mediated in vitro and in vivo responses in mugwort allergy. J. Allergy Clin. Immunol 111: 1328-1336, 2003

Krebitz, M., Wagner, B., Ferreira, F., Peterbauer, C., Campillo, N., Witty, M., Kolarich, D., Steinkellner, H., Scheiner, O., Breiteneder, H. Plant-based heterologous expression of Mal d 2, a thaumatin-like protein and allergen of apple (Malus domestica), and its characterization as an antifungal-protein. J. Mol. Biol. 329: 721-30, 2003

Hochreiter, R., Stepanoska, T., Ferreira, F., Valenta, R., Vrtala, S., Thalhamer, J., Hartl, A. Prevention of allergen-specific IgE production and suppression of an estabished Th2-type response by immunization with DNA encoding hypoallergenic derivatives of Bet v 1, the major birch pollen allergen. Eur. J. Immunol. 33: 1667-76, 2003

Bauer, R., Himly, M., Dedic, A., Ferreira, F., Josef Thalhamer, J., Hartl, A. Optimization of codon usage is required for effective genetic immunization against Art v 1, the major allergen of mugwort pollen. Allergy 58: 1003-10, 2003

Hochreiter, R., Ferreira, F., Thalhamer, J., Hammerl, P. Th1-promoting DNA immunization against allergens modulates the ratio of IgG1/IgG2a but does not affect anaphylactic potential of IgG1 antibodies: no evidence for the synthesis of non-anaphylactic IgG1. J. Allergy Clin. Immunol. 112: 579-84, 2003

Willerroider, M., Fuchs, H., Ballmer-Weber, B., Focke, M., Susani, M., Thalhamer, J., Ferreira, F., Wüthrich, B., Scheiner, O., Breiteneder, H., Hoffmann-Sommergruber, K. Cloning and Molecular and Immunological Characterization of Two New Food Allergens, Lyc e 1 and Cap a 2, Profilins From Bell Pepper (Capsicum annuum) and Tomato Int. Arch Allergy Immunol. 131: 245-55, 2003

Mari, A., Wallner, M., Ferreira, F. Fagales pollen allergy in a birch-free area: a population survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4). Clin. Exp. Allergy 33: 1419-1428, 2003

 

2002

Hiller, R., Laffer, S., Harwanegg, C., Huber, M., Schmid, W., Twardosz, A., Becker, W.M., Blaser, K., Breiteneder, H., Chapman, M., Crameri, R., Duchene, M., Ferreira, F., Fiebig., H., et al. Microarrayed allergen molecules: Diagnostic gatekeepers for allergy treatment. FASEB J. (January 14, 2002) 10.1096/fj.01-0711fje

Weiss, R., Scheiblhofer, S., Freund, J., Ferreira, F., Livey, I., Thalhamer, J. Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines. Vaccine 20: 31-48, 2002

Ferreira, F., Wallner, M., Breiteneder, H., Hartl, A., Thalhamer, J., Ebner, C. Genetic engineering of allergens: Future therapeutic products. Int. Arch. Allergy Immunol. 128: 171-178, 2002

Wopfner, N., Willeroider, M., Hebenstreit, D., van Ree, Ronald, Aalbers, M., Briza, P., Thalhamer, J., Ebner, C., Richter, K., Ferreira, F. Molecular and immunological characterization of profilin from mugwort pollen. Biol. Chem. 383: 1779-1789, 2002

Himly, M., Jahn-Schmid, B., Dedic, A., Kelemen, P., Wopfner, N., Altmann, F., van Ree, R., Briza, P., Richter, K., Ebner, C., Ferreira, F. (2002). Art v 1, the major allergen of mugwort pollen is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain. FASEB J 10.1096/fj.02-0472fje, FASEB J 17:106-8, 2003

Jahn-Schmid, B. Kelemen, P., Himly, M., Bohle, B., Fischer, G., Ferreira, F., Ebner, C. The T cell response to Art v 1, the major mugwort pollen allergen, is dominated by one epitope. J. Immunol. 169: 6005-6011, 2002

Geisberger, R., Prlic, M., Achatz-Straussberger, G., Oberndorfer, I., Luger, E., Lamers, M., Crameri, R., Appenzeller, U., Wienands, J., Ferreira, F., Achatz, G.
Phage display based cloning of proteins interacting with the cytoplasmic tail of membrane immunoglobulins. Developmental Immunology 9: 127-34, 2002

 

2001

Pertl, H., Himly, M., Gehwolf, R., Kriechbaumer, R., Strasser, D., Michalke, W., Richter, K., Ferreira, F., Obermeyer, G. Molecular and physiological characterisation of a 14-3-3 protein from lily pollen grains regulating the activity of the plasma membrane H+ATPase during pollen grain germination and tube growth.
Planta 213: 132-141, 2001

Ferreira F., Himly, M., Hebenstreit D., Dabrowska, M., Vollmann, U., Kraft, D., Obermeyer, G., Richter, K. Isolation and characterization of cDNA clones coding for Mugwort (Artemisia vulgaris) Pollen Allergens Int. Arch. Allergy Immunol., 124: 77-79, 2001

Simon-Nobbe, B., Kodzius, R., Kajava, A., Ferreira, F., Kungl, A., Achatz, G., Crameri, R., Ebner, C., Breitenbach, M.
Structure of an IgE-binding peptide from fungal enolases. Int. Arch. Allergy Immunol., 124: 93-94, 2001.

Hochreiter, R., Hartl, A., Freund, J., Valenta, R., Ferreira, F., Thalhamer J. The influence of CpG motifs on a protein or DNA-based Th2 type immune response against major pollen allergens Bet v 1a, Phl p 2 and Escherichia coli-derived ß-galactosidase. Int. Arch. Allergy Immunol. 124: 406-410, 2001

 

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