Sara Huber

Department Molecular Biology 
PhD Supervisor Univ. Prof. Dr. Fatima Ferreira
PhD Co-Supervisor Assoc. Prof. Dr. Michael Wallner
Start WS 13/14
Contact sara.huber(at)stud.sbg.ac.at
Doctoral Thesis Topic Mapping antibody profiles of Bet v 1 and associated food allergens during allergen-specific immunotherapy

Abstract

In the temperate climate zone of the Northern hemisphere birch pollen allergy represents the main cause of winter/spring pollinosis. More than 95% of birch pollen-allergic patients show sensitization to the major birch pollen allergen Bet v 1 of the white birch Betula verrucosa. Reactions to Bet v 1 affect over 100 million allergic patients worldwide.

The allergen-specific immunotherapy (AIT) still represents the only effective and long-lasting treatment of allergic diseases due to its potential to modulate the humoral immune response towards allergens by the induction of "blocking antibodies". However, at present no predictive serologic or cellular marker exists which can be used to determine the clinical efficacy of this treatment and to monitor antibody levels is insufficient.

By fully characterizing the antibody profiles during birch pollen AIT and studying whether therapy-induced blocking antibodies can also inhibit IgE binding to Bet v 1-related food allergens we aim to find such predictive markers and to investigate whether pollen-specific immunotherapy can be used to treat associated food allergies.

Bet v 1 and the related food allergens from hazelnut Cor a 1 and apple Mal d 1 are produced as recombinants, purified and characterized physico-chemically. For studying the humoral immune response towards these allergens different assays are performed including nasal provocation tests, ELISA, ImmunoCAP, immunoblots, facilitated antigen binding and rat basophil leukemia cell degranulation assays.

  • News
    The Paris Lodron University of Salzburg has launched an in-house mentoring program for new students as part of the “On Track” project. And it has come at the right time, because the lockdown has made the start of their studies into a real challenge for many first-semester students.
    18 participants recently completed the university course in early childhood education with a master's degree. The course was held for the second time in Salzburg. Regional Minister Andrea Klambauer awarded prizes to nine of the graduates for their outstanding theses.
    The recording of the PLUS Talks "Studies and Teaching WS 2020/21“ from 25.11.2020 is now available.
    Matthias Henke, musicologist, Danube University Krems, talks about Beethoven's current biography “Beethoven. Akkord der Welt ( Chord of the World)”, published in 2020 by Hanser Verlag.
    24 very easy exercises on 24 cards can be found in the SALTO advent calendar. The exercise ideas are ideal for children from the age of three and are also easy for the whole family to carry out in a small space. With the support of the Kinder Büro (Children's Office), this combinable contribution should benefit as many as possible.
    Researchers led by Salzburg's geoinformatics scientist Christian Neuwirth had already developed and presented a mathematical model for Covid-19 in May 2020 which examines the question of how long and intensively social distancing measures have to be maintained in order to reduce corona deaths further.
    Results of the study on media use by children and families during lockdown. Home schooling could be improved, but is on the right track. Secondary schools have a better profile. Families have learned to deal with lockdown and homeschooling.
    A study carried out by the sleep laboratory of the Faculty of Natural Sciences on the topic of sleep under the direction Prof. Dr. Manuel Schabus is dedicated to the changes in sleep during the Covid-19 lockdown in 6 different countries (Ö, AT, UK, GR, CU, BRA). The fear, which is worrying from a psychological point of view, and which is evident across society, is also reflected in this data: 78% of those surveyed feel threatened or worried by the Covid-19 pandemic.
    Online lecture on chemistry: December 2nd 2020 - 6 p.m. Emmanuelle Charpentier and Jennifer Doudna received the 2020 Nobel Prize in Chemistry for the discovery of one of the sharpest tools in genetic engineering: the CRISPR / Cas9 genetic scissors. With this technology, researchers can modify the DNA of animals, plants and microorganisms with extremely high precision.
    The PLUS Report 2020 has been published.
    Digitization has led to an enormous spread of different forms of mobile working. Corona has brought an additional boost and has introduced home office in areas and for activities that were previously unimaginable.
    During the time of Corona, in particular, it became clear just how important it is to support students digitally in their every day university life. The project „On Track“ – stay on track combines digital and social worlds. It is starting at the right time!
  • Veranstaltungen
  • 01.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    01.12.20 Der Körper als PLAYFUL TOOL
    02.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    02.12.20 PLUS startupSPRECHTAG - gather your ideas
    02.12.20 Musikpyhsiologie und Musikermedizin: Musizieren im Zusammenwirken von Psyche und Körper
    02.12.20 Nobelpreise 2020 - CHEMIE (Genschere)
    03.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    04.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    04.12.20 Ideen mit Methode
    05.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    06.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
    07.12.20 Adventkalender der Universitätsbibliothek Salzburg 2020
  • Alumni Club
  • PRESS
  • University of Salzburg's facebook site University of Salzburg's twitter site University of Salzburg's instagram site University of Salzburg's flickr site University of Salzburg's vimeo site