Sabrina Wildner

Department Molecular Biology 
PhD Supervisor Univ. Prof. Dr. Fatima Ferreira
PhD Co-Supervisor Dr. Gabriele Gadermaier
Start SS 14
Contact sabrina.wildner(at)
Doctoral Thesis Topic Structural and immunological characterization of biosimilars and allergens


Biopharmaceuticals (biologics) are protein molecules produced in living cells and used in therapy for a wide range of disorders like cancer, autoimmune or autoinflammatory diseases. In contrast to small molecule drugs, biologics are highly sensitive to their manufacturing and handling conditions. The production of biopharmaceutical drugs in living cells can thus result in minor conformational differences due to posttranslational modifications, different codon usage, etc. These subtle conformational changes can however impact the safety, efficacy and stability of the product and can remain undetected by analytical methods. A new tool termed aptamers can help to detect changes in three-dimensional structures of biopharmaceutical products. Aptamers are short, single-stranded oligonucleotides which can adopt specific three dimensional shapes. SELEX (systematic evolution of ligands by exponential enrichment) is a technique for screening large oligonucleotide libraries and is used for in vitro selection and amplification. My aim is to select a panel of aptamers reactive against an antibody-based biopharmaceutical. Aptamers can be used as surrogate antibodies in ELISA assays to characterize potential conformational differences between originator and biosimilar, monitor a production process or determine structural changes during shelf life of a product.

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    More than a hundred participants, who were interested in and supporters of ditact, met yesterday in Unipark Nonntal for the opening of this year's ditact_women's IT summer studies. Two hundred and sixteen participants from all over German-speaking countries have registered for the 46 IT and Digital University Information Technology (IT) Summer University courses, which will run for two weeks at the Unipark Nonntal and are being carried out for the seventeenth time by the University of Salzburg.
    For her dissertation "Die Ortsnamen im Lungau", the doctoral student, Magdalena Schwarz, was awarded the DOC scholarship of the Austrian Academy of Sciences (ÖAW) at the Department of Linguistics of the University of Salzburg.
    The Salzburg Armenologist, Jasmine Dum-Tragut, opens the first exhibition on 31 August, 2019, at the Genocide Museum in Yerevan. The exhibition shows the fate of Armenian prisoners of war in the Austrian prison camps during the First World War.
    At the end of the Salzburger Hochschulwochen, outgoing Rector Heinrich Schmidinger pleaded for contemporary humanism in response to a complex and confused world. Anyone who gives in to the longing for simplicity will ring in the hour of ideology.
    Democracy and the rule of law seem to have experienced better times in Europe. The recent developments in many countries point to a dismantling of the rule of law, fundamental rights and democracy.
    The Botanical Garden invites you to a free guided tour! Meeting point: entrance to the Botanical Garden. Duration: about two hours. The tours takes place in all weather conditions. Botanical Garden, Hellbrunnerstrasse 34.
    The 7th Salzburg Summer School will take place the 2nd and 3rd of September, 2019. A comprehensive pedagogical summer education program is offered for teachers and student teachers of all types of schools and subjects. Registrations are possible.
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