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AG F. Aberger
The group studies signaling pathways in malignant cancer stem cells responsible for tumor growth, metastasis and disease relapse with the aim to develop treatments that eradicate cancer stem cells by targeted therapy and reactivation of the anti-tumoral immune response.  



AG  H. Brandstetter
The group studies the structure and function of protein complexes in proteolysis and peptide ligation. We exploit this mechanistic understanding to address important questions such as the immune recognition of molecules, with relevance in allergy and cancer.



AG C. Cabrele
Elucidation of protein-protein interactions meets drug design for a synergistic approach to cancer research. Looking at proteins of interest (e.g., DNA transcription regulators) at the atomic level, the group reproduces natural structures into synthetic architectures whose function matches/counteracts the native one.  

Barrierefreiheit: Kurzbeschreibung des Bildes
AG O. Diwald
The group has profound expertise in the functional property characterization of surfaces and interfaces within nanostructured solids. Related research activities have recently extended to the study of protein interaction with nanoparticle ensembles and the impact of agglomeration on adsorption and biological activity.



AG  A. Duschl
The topics of the group cover nanoparticles and human health, principles of bio-nano interaction, nanosafety, complexes between  nanoparticles and allergens, as well as signal transduction and gene expression in the immune system, regulated by NLR, TLR and cytokine receptors.



AG  F. Ferreira
The group investigates how allergens and allergen source-derived factors shape TH2-biased immune responses. Our major aims are to decipher the mechanisms of allergic sensitization to pollen and to translate basic findings into novel approaches to allergy prevention and therapy.

Barrierefreiheit: Kurzbeschreibung des Bildes
AG  I. Gratz
The work group studies the function of T cells in the skin, with the aim to elucidate the generation of suppressive, regulatory T cells in autoimmunity, and the role of skin resident T cells in skin wound healing and skin cancer.



AG N. Hüsing
The group synthesizes tailor-made inorganic-organic (hybrid) nanomaterials (particles, film, etc.). Starting from deliberately designed precursor molecules, the structure and composition of the from sol-gel processes resulting synthetic nanomaterials is investigated to obtain a deeper insight in synthesis-structure- property relationships.



AG C. Huber
The team focuses its activities toward the establishment of experimental and computational workflows for cancer and allergy models by untargeted "-omics" analyses, which aims at generating unbiased hypotheses for studying molecular mechanisms of allergy and cancer.

Barrierefreiheit: Kurzbeschreibung des Bildes

AG A. Risch
The work group focusses on genetic and epigenetic variations and aberrations in the context of cancer, with the aim of identifying biomarkers of exposure or diagnostic/prognostic markers, as well as new mechanisms in carcinogenesis.



AG  J. Thalhamer
The group develops novel approaches for the treatment of allergies including RNA and DNA vaccines, epicutaneous vaccination, and nanoparticle formulations. In this context, we explore the role of immune cells in the skin and the influence of fold-stability of proteins on immunogenicity and allergenicity.



AG S. Wessler
Infections with Helicobacter pylori are associated with inflammation and gastric cancer. The research of the group focuses on sophisticated mechanisms of pathogen-host interactions which require a complex network of bacterial effector proteins, proteases, etc. interfering with host cell functions and signal transduction pathways.

Contact information:

University of Salzburg
Department of Molecular Biology
Division of Allergy and Immunology
Hellbrunnerstraße 34
5020 Salzburg
Austria 

Tel.: +43 (0)662 8044 5730
        +43 (0)662 8044 5577
Fax: +43 (0)662 8044 5751

 

 

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