MorphoPhysics Group

The ability of biological tissues to change both their external shape and internal structure, allows organisms to grow, to adapt to their environment, and even to heal damage. Shape changes may even perform a function in tissues without an active metabolism, such as found in seed dispersal units in the plant world. These processes of morphogenesis are mediated by biochemical and genetic signals operating within the physical constraints of their surroundings. The importance of these physical constraints has become clearer in recent years with the observation that cells and growing tissues indeed respond to mechanical signals. Such mechanical signals may arise due to loads acting on the external boundary or even be created by active stress-generating processes occurring inside the tissue itself.

In our research group we explore how mechanical and geometric boundary constraints influence growing and swelling tissues using a combination of theoretical and experimental techniques. The following research topics come from work that was carried out with Peter Fratzl, in the Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. 

Tissue Growth

Tissue growth on wave

Fig. 1Confocal microscopy image of actin-stained tissue grown on wavy surface (Gamsjaeger et al 2013)

In addition to being controlled by biochemical and genetic factors, tissue growth is also influenced by the physical properties of the local cell environment such as stiffness and shape. We are particularly interested in evidence that the local geometry, namely the surface curvature of the substrate, controls the rate of cell proliferation and resultant tissue growth. Our goal is to combine theoretical models for tissue growth with in-vitro cell-culture experiments visualised using advanced 4D microscopy methods in order to understand the observed dependence of growth behaviour on curvature. We then aim to use our models to better understand the role of geometry on processes such as bone healing and remodelling.

Morphing Materials

3D Printed Actuator

Fig 23D printed swellable honeycombs before and after swelling (Guiducci et al, 2015)

We are inspired by the hygroscopic movements of plant organs, such as those seen in the pine cone and other seed dispersal units. These systems are particularly interesting in that the organs are both structure and motor in one, the motion being controlled by the geometric arrangement of constituent tissues with different swellabilities. The focus of our group in this direction is to understand and develop models (both theoretical and physical) of 3D motion. We work closely with biologists to understand the opening mechanisms of plant-based actuators. We then aim to apply the design principles learnt to new biomimetic composites (together with synthetic chemists) and create prototypes using advanced 3D (or 4D) printing technology.

Structure Function Relationships in Biological Materials

Ashby Map

Fig 3: Materials property chart for biological materials based on (Wegst and Ashby, 2004).

Although a large range of types and forms of tissues can be found in Nature, it is somewhat surprising that the majority of structural tissues are made of only a limited range of components. This wide coverage of "materials-space" comes about from the fact that tissues are essentially composite materials, combining different physical properties from each of the constituent building blocks. By just controlling the architecture (or microstructure) of these constituents at different length scales, as well as the composition and structure of internal interfaces, Nature can achieve a wide range of different properties with the same components. In our group we are interested investigating such (micro)structure-function relationships in biological materials and in particular to shed-light on how these structures come about. We hope not only to learn more about biology but also to learn mechanical principles that can potentially be used in the design of synthetic materials.

Simulating Active Particle Motion

Active Particles swarming around umbilical point

Fig. 4: Collective motion of active particles tends to swarm around umbilical points (red) on ellipsoidal surfaces (Ehrig et al 2017).

When autonomously moving objects start interacting with a sufficient number of other such objects in space, then complex patterns of collective motion can start to appear.  Classic examples include the schooling of fish, the swarming of insects and the flocking of birds. In our group we are interested in how such models can be extended to active objects confined to curved surfaces, to explore how the local topology and curvature influences the resultant pattern formation. Our eventual goal will be to apply such models to examples in biology where actively propelled objects such as cells, are confined to curved surfaces.

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    A team led by the Salzburg-based young researcher, Therese Wohlschlager, has developed an approach that allows biopharmaceuticals to be characterized more easily and faster than before, and subsequently, can be produced more cheaply.
    Information Event "Unifinanzierung NEU (Fokus Lehre) und Zielvereinbarungsprozess" will be held Tuesday, 16 October, 2018, from 15:00 to 17:00, Thomas Bernhard Hörsaal in the Unipark.
    Orientation Week takes place from 17 - 21 September, 2018.
    Play with - International Stallcatchers Catchathon 2018!
    On Friday, 7 September, 2018, in Berlin, the project "Making Art, Making Media, Making Change!", by Elke Zobl (Associate Professor of Science & Art), received the European Youth Culture Award (EYCA) in the category of "Science and Research”.
    Exhibition opening and conversation with Jian Haake (Kiel). Date: Thursday, 4 October at 18:30. Location: Room for Art at KunstQuartier, Bergstraße 12a. Exhibition Duration: From 5 October until 9 November, 2018.
    The University Library Salzburg (Main Library and Faculty Library for Law) opens the door to the public and offers a diverse program.
    Political education has been a general teaching principle in Austria since 1978, that is, an educational and developmental task, which is the responsibility of the teachers of all school subjects and grades. The lecture series will show ways in which democracy education can work in different subjects, so that student teachers and educators have different perspectives on the same fundamental challenge.
    On the occasion of the Long Night of the Museums 2018, the Casting Collection of the University of Salzburg will be open to the public.
    Putting Successful Models Into Perspective in Europe, 26 – 28 September, 2018, Schloss Rif, University of Salzburg. For students there are discounted day tickets!
    New Watercolors • Eva Pötzelsberger
    Important dates and information about registering for courses at the Language Center in the Winter Semester 2018/19.
    Brothers Leopold (6 years) and Ferdinand (4 years) explained to their friends: "We go to UNI during the holidays" and were right. They had places in the fully booked summer care program of the University’s Kinderbüro.
    The Leopold Kohr Academy has organized two events, one in September and another in October, 2018. Together with the University of Salzburg, the institution runs the Kohr Archive.
    On Saturday, 22 September, 2018, at 11:00, the Botanical Garden will be displaying the images of the artist, Karin Wimmeder. Only in fair weather. Alternative date: Saturday, 29 September, 2018, 11:00. Musically accompanied by the rhythm group "".
    From Hortus Medicus to Pharma Research. An exhibition of the Association of Botanical Gardens 2018.
    On 6 December, 2018, the University of Salzburg will host the WTZ Training Days on the theme of communication, dissemination and distribution in H2020 projects.
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    19.09.18 Magnetoencephalography in Salzburg; past, present and future
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    20.09.18 „Reisenotizen und Landschaftsfantasien“ neue Aquarelle • Eva Pötzelsberger
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    25.09.18 Welcome Day/Orientierungstag für Erstsemestrige
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