Structural Biology Group

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The research of our team focuses on proteolytic enzymes, their cofactors, substrates and inhibitors. Proteolytic enzymes are master switchers in health and disease. By their highly specific recognition and modification of protein substrates, proteases serve as signaling and decision matrices. Of particular interest to us are proteolytic actions in the field of immunology/allergy, blood coagulation, and cancer.

We employ a broad spectrum of biochemical, biophysical and computational techniques to characterize the molecular function of important target proteins. Most importantly, we use x-ray crystallography to determine the three-dimensional architecture of the molecular targets. The structural information guides us to rationalize and experimentally test hypotheses about possible molecular mechanisms of action as well as their significance in the molecular, cellular and systemic context.

Questions of immunological interest are linked to the cellular pass control which is implemented via antigen processing and presentation. Each cell has to identify itself towards the immune system by presenting intracellular peptides at the cell surface. Despite its enormous efficiency, some harmful cells escape the screening (pass control) of the immune system, e.g., by presenting unsuspicious peptides only. On the other side, allergens, which are harmless proteins, can trigger excessive immune reactions. We investigate the complex protease machines involved in antigen processing. A detailed understanding promises treatment options against immunological and infectious diseases, and also tumors.

The (innate) immune system is multiply linked to the blood coagulation system which primarily serves to stop life-threatening bleeding without causing fatal vessel occlusions (thrombosis). For this purpose nature employs a molecular proofreading principle that requires simultaneous and concerted molecular actions. We investigate disharmonies in these molecular orchestra that lead to bleeding disorders such as hemophilia.

Research Projects

This resarchgroup is member of the international "PhD program ICA" of the University of Salzburg and the FWF, and a member of the  " Allergy-Cancer-BioNano Research Centre " of the University of Salzburg.

 

  • News
    On 19 June, at 19:00, Dorothea Macheiner (Hg.), Ludwig Laher and Michael Kolnberger will present the newly published volume, "Gerold Foidl: Gesammelte Werke. Der Richtersaal. Scheinbare Nähe. Standhalten", in the Literaturarchiv Salzburg.
    Rita Grandori will give a guest lecture on the topic, "Protein conformational transitions and intermolecular interactions by native mass spectrometry and complementary biophysical methods" at 16:00 on 27 June, 2018 in the Hörsaal 403 of the NW-Faculty. The Department of Life Sciences invites you to join!
    Herr PD Dr. Reinhard Jung (Austrian Academy of Sciences, OREA) will give a lecture on 16 June on "Mykenisches Griechenland und Italien: verschiedene Arten des Gebens und Nehmens". Time: 18:30 - Location: Abguss-Sammlung SR E.33, Residenzplatz 1.
    Romana Limberger will give a guest lecture on "Food Webs in Changing Environments" at 14:00 on 29 June, 2018, in Hörsaal 421 of the NW faculty. The Department of Life Sciences invites you to join!
    Thanks to a generous legacy on the part of Mr. Kurt Zopf, the University of Salzburg is awarding the Kurt Zopf Prize for Habilitation, endowed with 10,000 Euros, to the qualifying university professors. This year's competition is aimed at the fields of science, human medicine and technical sciences.
    Christoph Czerwenka will hold a guest lecture on 27 June, 2018, at 14:00 in Hörsaal 403 of the NW-Faculty on the topic, "Food Contaminants - Constant New Challenges for the Analytical Chemist". The Department of Life Sciences invites you to join!
    The Digitization of the Economy and Industry 4.0 is on everyone's lips. Capitalist society is changing and at the same time it remains capitalist. What's new? How does the old live on in the new? How can we all shape technological developments to serve the good of society as a whole? The speakers address these questions from different perspectives.
    The 6th Salzburg Summer School will take place from 3 to 4 September, 2018. For two days, a comprehensive pedagogical summer education program will be offered to teachers and student teachers of all types of schools and subjects. Registration is possible.
    Peter Kaufmann will hold a guest lecture on 22 June, 2018, at 14:00 in Hörsaal 421 of the NW-Faculty on "Herpetological projects at the Haus der Natur: From data management to nature conservation to population ecology studies". The Department of Life Sciences invites you to join!
    Satyr choir versus "loneliest song". On Nietzsche's aesthetics of the choral.
    Dr. Julia Krivoruchko (Cambridge) - Thu 21.6.2018, 18:00 c.t., Room 3.443 (Unipark)
    From 21 June to 14 September, 2018, the extremely versatile, freelance visual artist Christiane Pott-Schlager, who lives and works in Lamprechtshausen, will present new works in the Aula-Gang / 1st floor of the University Library Salzburg.
    On Wednesday, 20 June, 2018, starting at 19:00, the seventh Nightshift@UBS, in cooperation with the ÖH Salzburg, will take place in the Hauptbibliothek.
    Ulrich Brand, Professor of International Politics at the University of Vienna, talks about the book "Imperiale Lifestyle", co-authored with Markus Wissen. Book presentation and discussion on 20.06.2018 at 19:00 h in the HS Anna Bahr-Mildenburg / Unipark Nonntal
    The History Schoolbook: Learning - Teaching - Researching.
    From Hortus Medicus to Pharma Research. An exhibition of the Association of Botanical Gardens 2018.
    Rafael Jové (Media Artist, Weimar) 12 – 19 June, 2018: Müllner- Brückenkopf Mozartsteg (right side of the old town)
    12 June – 10 July, 2018 - enter: Room for Kunst at KunstQuartier, Bergstraße 12a, 5020 Salzburg, ground floor.
    This Aniversary Year, the KinderUNI is looking for those who participated at the very beginning of the program! Who attended the first KinderUNIs here in Salzburg in 2004 or 2006?
    Friday, 8 June: 09:45 KEYNOTE: Eliot Borenstein (New York): Plots Against Russia: Conspiracy, Sincerity, and Propaganda // 17:30 ROUND TABLE: Why Do Conspiracy Theories Thrive in Post-Soviet Russia? with Alexander Panchenko, Konstantin Bogdanov, Sergey Shtyrkov, Svetlana Tambovtseva (St. Petersburg) // Erzabt-Klotz-Str. 1, FB Slavic Studies, 3rd floor.
    From now until 3 July is the registration period for the ditact_women's IT Summer School of the University of Salzburg, which will take place from 20 August to 1 September, 2018, at the Unipark Nonntal and at the Fachhochschule Salzburg.
    Education on the subject of Summer School 4 - 5 July, 2018
    Silvia Naef (Geneva) speaks on 20 June at 18:00 in the Unipark Nonntal as part of the public lecture series LEGEND AND EXPLANATION: RELIGIOUS POLEMIK AGAINST ART - ARTISTIC POLEMIK AGAINST RELIGION on religion and art in the Islamic field. www.w-k.sbg.ac.at/de/kunstpolemik-polemikkunst/aktuelles
    DANIEL FULDA (Martin-Luther-University Halle-Wittenberg) concludes the public lecture series, LEGALIZATION AND DISCLOSURE: RELIGIOUS POLEMIK AGAINST ART - ARTISTIC POLEMIK AGAINST RELIGION, on 27 June at 18:00 in the Unipark Nonntal with his lecture on meaning and the search for meaning in the literature of the German Enlightenment. http://www.w-k.sbg.ac.at/de/kunstpolemik-polemikkunst
  • Veranstaltungen
  • 19.06.18 Kanonische Texte
    20.06.18 Religion und Kunst im islamischen Bereich – Theorie und Praxis
    20.06.18 7. Nachtschicht@UBS
    21.06.18 7. Nachtschicht@UBS
    21.06.18 50 Jahre Soziologie in Salzburg
    21.06.18 50 Jahre Soziologie in Salzburg
    21.06.18 Info-Veranstaltung Psychotherapeutisches Propädeutikum
    21.06.18 Ungreifbare Materien - Zu Farbe und Klang in der Kunst (James Turrell, Morton Feldman)
    21.06.18 Bilder - Zeichnungen - Stahlobjekte • Christiane Pott-Schlager
    22.06.18 Kapitalismus 4.0: Digitalisierung - Finanzkapital - Alternativen
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