Structural Biology Group

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The research of our team focuses on proteolytic enzymes, their cofactors, substrates and inhibitors. Proteolytic enzymes are master switchers in health and disease. By their highly specific recognition and modification of protein substrates, proteases serve as signaling and decision matrices. Of particular interest to us are proteolytic actions in the field of immunology/allergy, blood coagulation, and cancer.

We employ a broad spectrum of biochemical, biophysical and computational techniques to characterize the molecular function of important target proteins. Most importantly, we use x-ray crystallography to determine the three-dimensional architecture of the molecular targets. The structural information guides us to rationalize and experimentally test hypotheses about possible molecular mechanisms of action as well as their significance in the molecular, cellular and systemic context.

Questions of immunological interest are linked to the cellular pass control which is implemented via antigen processing and presentation. Each cell has to identify itself towards the immune system by presenting intracellular peptides at the cell surface. Despite its enormous efficiency, some harmful cells escape the screening (pass control) of the immune system, e.g., by presenting unsuspicious peptides only. On the other side, allergens, which are harmless proteins, can trigger excessive immune reactions. We investigate the complex protease machines involved in antigen processing. A detailed understanding promises treatment options against immunological and infectious diseases, and also tumors.

The (innate) immune system is multiply linked to the blood coagulation system which primarily serves to stop life-threatening bleeding without causing fatal vessel occlusions (thrombosis). For this purpose nature employs a molecular proofreading principle that requires simultaneous and concerted molecular actions. We investigate disharmonies in these molecular orchestra that lead to bleeding disorders such as hemophilia.

Research Projects

This resarchgroup is member of the international "PhD program ICA" of the University of Salzburg and the FWF, and a member of the  " Allergy-Cancer-BioNano Research Centre " of the University of Salzburg.

 

  • News
    In the 41st Salzburg Lecture, Roman Sandgruber will present his latest work on the fascinating rise and fall of the "Rothschild Welthaus".
    36th Statute of the Paris Lodron University Salzburg (version 2018) The two University Salzburg doctoral students Christoph Hülsmann, Romance Studies, and Dr. James Wilhelm, Political Science, received the State Prize of the BMBWF for their dissertations "On the Information Structure and its Interfaces in Spoken Language (French, Spanish, Italian)" and "Does the EU Theme Affirm the Election - Political Parties, European Integration and
    In July 2018, the international research project "Processing Instruction for L3: Differences between balanced and unbalanced bilinguals (PI-BI-L3)" received funding from the Austrian Federal Ministry of Education, Science and Research (BMBWF) and the Macedonian Ministry of Education and Research (MON) awarded by the Austrian Exchange Service (OeAD) Competition for 24 months
    As part of the film series "Filmclub Horizonte" at the Salzburger Filmkulturzentrum "Das Kino", Giselakai 11, in Salzburg on 13.12.18 and 10.1.19 the two films "Leto" and "Breaking the Limits".
    13 December: "On the scientific influence of Judaism on the non-Jewish world" (M. Joel) - On a research program of the Wroclaw Jewish Theological Seminary Thu 13.12.2018, 18:00 c.t., HS E.002 (Unipark) - PD Dr. Görge K. Hasselhoff (TU Dortmund)
    The DSP-Kolleg Popular Culture Studies is organizing a lecture series entitled "Approaches in Popular Culture Studies" during the winter term 2018/19. The second session will take place on 14 December from 11:00 to 13:00 at the Unipark (Room 2.138) and will cover the topic "Decolonization and Postcolonial Cinema In Canada, Brazil, Australia and Nigeria".
    On Fri 14 December, at 13:00. Alexander Mirnig will give a lecture "On Autonomous Driving", and Werner Sattlegger will speak about "Innovation in Silicon Valley". The venue is Hörsaal 380, Gesellschaftswissenschaften, Rudolfskai 42.
    Tuesday, 18 December, 2018, 12:15 - 15:00, HS 101 of the Faculty of Catholic Theology (Universitätsplatz 1, Salzburg, ground floor) - Theme: Practice as a Stimulus for Knowledge.
    For the benefit of DEBRA Austria - Help for children suffering from epidermolysis bullosa, known as the butterfly children.
    "Silent Night, Holy Night" - a Song that Goes Around the World On 24 December, 1818, Joseph Mohr and Franz Xaver Gruber agreed for the first time on the song "Silent Night, Holy Night" in Oberndorf, near Salzburg. From here, the song made its way around the world and is sung by around two billion people in over 300 languages and dialects at Christmas.
    Conference "Equality in Europe" on the occasion of the 100th anniversary of the introduction of women's suffrage in Central and Western Europe.
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    12.12.18 zugunsten von DEBRA Austria - Hilfe für die Schmetterlingskinder
    13.12.18 „Stille Nacht, heilige Nacht“ - ein Lied geht um die Welt
    13.12.18 zugunsten von DEBRA Austria - Hilfe für die Schmetterlingskinder
    13.12.18 Simulation of nonlinear bending phenomena: convergence, self-avoidance and applications
    13.12.18 Vorträge der Salzburger Juristischen Gesellschaft
    14.12.18 „Stille Nacht, heilige Nacht“ - ein Lied geht um die Welt
    14.12.18 zugunsten von DEBRA Austria - Hilfe für die Schmetterlingskinder
    14.12.18 DECOLONIZATION AND POSTCOLONIAL CINEMA IN CANADA, BRAZIL, AUSTRALIA, AND NIGERIA
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    17.12.18 „Stille Nacht, heilige Nacht“ - ein Lied geht um die Welt
    17.12.18 zugunsten von DEBRA Austria - Hilfe für die Schmetterlingskinder
    18.12.18 „Stille Nacht, heilige Nacht“ - ein Lied geht um die Welt
    18.12.18 zugunsten von DEBRA Austria - Hilfe für die Schmetterlingskinder
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