Structural Biology Group

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The research of our team focuses on proteolytic enzymes, their cofactors, substrates and inhibitors. Proteolytic enzymes are master switchers in health and disease. By their highly specific recognition and modification of protein substrates, proteases serve as signaling and decision matrices. Of particular interest to us are proteolytic actions in the field of immunology/allergy, blood coagulation, and cancer.

We employ a broad spectrum of biochemical, biophysical and computational techniques to characterize the molecular function of important target proteins. Most importantly, we use x-ray crystallography to determine the three-dimensional architecture of the molecular targets. The structural information guides us to rationalize and experimentally test hypotheses about possible molecular mechanisms of action as well as their significance in the molecular, cellular and systemic context.

Questions of immunological interest are linked to the cellular pass control which is implemented via antigen processing and presentation. Each cell has to identify itself towards the immune system by presenting intracellular peptides at the cell surface. Despite its enormous efficiency, some harmful cells escape the screening (pass control) of the immune system, e.g., by presenting unsuspicious peptides only. On the other side, allergens, which are harmless proteins, can trigger excessive immune reactions. We investigate the complex protease machines involved in antigen processing. A detailed understanding promises treatment options against immunological and infectious diseases, and also tumors.

The (innate) immune system is multiply linked to the blood coagulation system which primarily serves to stop life-threatening bleeding without causing fatal vessel occlusions (thrombosis). For this purpose nature employs a molecular proofreading principle that requires simultaneous and concerted molecular actions. We investigate disharmonies in these molecular orchestra that lead to bleeding disorders such as hemophilia.

Research Projects

This resarchgroup is member of the international "PhD program ICA" of the University of Salzburg and the FWF, and a member of the  " Allergy-Cancer-BioNano Research Centre " of the University of Salzburg.

 

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    Scientists at the University of Salzburg have examined the international impact of a Brexit shock on selected Eurozone member states and Great Britain.
    On 6 February, in the presence of the Austrian Ambassador Mag. Christian Ebner, Prof. DDr. DDr.h.c. J. Michael Rainer, Department of Private Law, Dean of the Faculty of Law, was presented the award "Ursicinio Alvarez" of the Spanish Notary for his services to Roman law in Madrid.
    This year, the Knowledge Network Law, Economy and Labor, together with the Vienna Center for Legal Informatics (WZRI) of the University of Vienna, has organized what is now the largest and most important scientific conference in Austria and Central Europe in the field of legal informatics: the International Legal Informatics Symposium IRIS. The event will be held from February 21 to 23, 2019, at the Faculty of Law of the University of Salzburg.
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    The University of Salzburg and the Wissensstadt Salzburg invite the general public to the international Open NanoScience Congress at the Unipark Nonntal on 26 February, 2019. Scientists offer insights into current research projects, whether on nanosafety or novel nanomaterials. The students from the Sparkling Science Project "Nan-O-Style" are also involved in the Congress and will present their work on nanomaterials in modern lifestyle products.
    For many years now, the international research team of Angela Schottenhammer has been collecting and editing Chinese sources on maritime Asia.
    The ONSC will take place on Tuesday, 26 February, 2019, from 9:00 – 13:00 in the Unipark Nonntal, Salzburg.
    Prof. Dr. Angela Schottenhammer is part of a multi-disciplinary, international team of scholars under the directorship of Professor Gwyn Campbell of McGill University that has been awarded a $2.5 million partnership grant funded by the Social Sciences and Humanities Research Council of Canada (SSHRC) to investigate six periods of historical and contemporary environmental (e.g. climate change, volcanism, monsoons, cyclones, drought) ...
    Important dates and information for registering with the Language Centre for courses offered during the Summer Semester 2019.
    The (English-language) seminar on “Transnational Supply Chains and Domestic Human Rights Litigation” deals with legal questions that arise when human rights abuses in transnational supply chains give rise to domestic law suits.
    Summer Term 2019: Seminar Space Law …with an excursion to the European Space Agency and a visit to the new VEGA observatory.
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  • 20.02.19 IRIS 2019
    21.02.19 IRIS 2019
    21.02.19 Orientation Week SoSe 2019: Unipark Bibliothek - Information und Führung (Deutsch)
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    21.02.19 Orientation Week SoSe 2019: Unipark library - information and tour (English)
    21.02.19 Orientation Week SoSe 2019: fortress tour
    21.02.19 IRIS 2019
    22.02.19 IRIS 2019
    22.02.19 Orientation Week SoSe 2019: main library - information and tour (English)
    22.02.19 Orientation Week SoSe 2019: Hauptbibliothek - Information und Führung (Deutsch)
    23.02.19 IRIS 2019
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