Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P. Sci Rep. doi: 10.1038/s41598-018-29058-6.(2018)

 

Activation and activity of glycosylated KLKs 3, 4 and 11. Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P. Biol Chem.doi: 10.1515/hsz-2018-0148. (2018)

 

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states. Dall E, Hollerweger JC, Dahms SO, Cui H, Häußermann K, Brandstetter H. J Biol Chem. doi: 10.1074/jbc.RA118.002154. (2018)

 

Specificity profiling of human trypsin-isoenzymes. Schilling O, Biniossek ML, Mayer B, Elsässer B, Brandstetter H, Goettig P, Stenman UH, Koistinen H. Biol Chem. doi: 10.1515/hsz-2018-0107.(2018)

 

Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates. Zauner FB, Elsässer B, Dall E, Cabrele C, Brandstetter H. J Biol Chem.doi: 10.1074/jbc.M117.817031. (2018)

 

Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples. Hollerweger JC, Hoppe IJ, Regl C, Stock LG, Huber CG, Lohrig U, Stutz H, Brandstetter H. Anal Chem. doi: 10.1021/acs.analchem.7b04874. (2018)

 

Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation. Zauner FB, Dall E, Regl C, Grassi L, Huber CG, Cabrele C, Brandstetter H. Plant Cell. doi: 10.1105/tpc.17.00963. (2018)

 

Schinagl A, Kerschbaumer RJ, Sabarth N, Douillard P, Scholz P, Voelkel D, Hollerweger JC, Goettig P, Brandstetter H, Scheiflinger F, Thiele M. Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch Biochemistry. doi: 10.1021/acs.biochem.7b01156.(2018)

 

Soh WT, Briza P, Dall E, Asam C, Schubert M, Huber S, Aglas L, Bohle B, Ferreira F, Brandstetter H. Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci. doi: 10.3390/ijms18102156. (2017)

 

Elsässer B, Zauner FB, Messner J, Soh WT, Dall E, Brandstetter H. Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations. ACS Catal. doi: 10.1021/acscatal.7b01505. (2017)

 

Schönauer E, Kany AM, Haupenthal J, Hüsecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsässer B, Ducho C, Brandstetter H, Hartmann RW. Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J Am Chem Soc. doi: 10.1021/jacs.7b06935. (2017)

 

Wildner S, Elsässer B, Stemeseder T, Briza P, Soh WT, Villalba M, Lidholm J, Brandstetter H, Gadermaier G. Endolysosomal Degradation of Allergenic Ole e 1-Like Proteins: Analysis of Proteolytic Cleavage Sites Revealing T Cell Epitope-Containing Peptides. Int J Mol Sci. doi: 10.3390/ijms18081780. (2017)

 

Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer`s disease. Nat Commun. doi: 10.1038/ncomms14740. (2017)

 

Braga SF, Martins LC, da Silva EB, Sales Júnior PA, Murta SM, Roanha AJ, Sow WT, Brandstetter H, Ferreira RS, de Oliveira RB. Synthesis and biological evaluation of potential inhibitors of the cysteine porteases cruzain and rhodesain designed by molecular simplification. Bioorg Med Chem. doi: 10.1016/j.bmc.2017.02.009 (2017)

 

Stemeseder T, Freier R, Wildner S, Fuchs JE, Briza P, Lang R, Batanero E, Lidholm J, Liedl KR, Campo P, Hawranek T, Villalba M, Brandstetter H, Ferreira F, Gadermaier G. Crystal structure of Pla I 1 reveals both structural similarity and allergenic divergence within the Ole e1-like protein family. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2016.10.035. (2016)

 

Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME. The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers. Sci Rep. doi: 10.1038/srep34303. (2016)

 

Debela M, Magdolen V, Bode W, Brandstetter H, Goettig P. Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10. Biol Chem. doi: 10.1515/hsz-2016-0205. (2016)

 

Abfalter CM, Schönauer E, Ponnuraj K, Huemer M, Gadermaier G, Regl C, Briza P, Ferreira F, Huber CG, Brandstetter H, Posselt G, Wessler S. Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC14579. PLoS One. doi: 10.1371/journal.pone.0162433. (2016)

 

Kristensen LH, Olsen OH, Blouse GE, Brandstetter H. Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem J. doi: 10.1042/BCJ20160336. (2016)

 

Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P. Single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity. J Biol Chem. pii: jbc.M115.691097. (2015)

 

Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. J Allergy Clin Immunol. pii: S0091-6749(15)01366-4. doi: 10.1016/j.jaci.2015.09.026. (2015)

 

Dall E, Brandstetter H. Structure and function of legumain in health and disease. Biochimie. pii: S0300-9084(15)00297-7.doi: 10.1016/j.biochi.2015.09.022. (2015)  

 

Freier R, Dall E, Brandstetter H. Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity. Sci Rep. doi: 10.1038/srep12707 (2015)

 

Wolkerstorfer S, Schwaiger E, Rinnerthaler M, Karina Gratz I, Zoegg T, Brandstetter H, Achatz-Straussberger G. HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis. doi: 10.1038/cmi.2015.018.

 

Dall E, Fegg JC, Briza P, Brandstetter H. Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew Chem Int Ed Engl. 54(10): 2917-21.(2015)

 

Grutsch S, Fuchs JE, Frier R, Kolfer S, Bibi M, Asam C, Wallner M, Ferreira F, Brandstetter H, Liedl KR, Tollinger M. Ligand binding modulates the structural dynamicvs and compactness of the major birch pollen allergen. Biophys. J. 107(12): 2963-72.(2014)

 

Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P. Structure-Function Analyses of Human Kallikrein-Related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity. J Biol Chem. Pii: Jbc.M114.598201 (2014)  

 

Guo S, Skala W, Magdolen V, Brandstetter H, Goettig P. Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity. Biol Chem. 395(9):959-76. (2014)  

 

Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, Asam C, von Grafenstein S, Fuchs JE, Briza P, Liedl KR, Bohle B, Ferreira F, Brandstetter H, Oostingh GJ, Duschl A. The impact of nitration on the structure and immunogenicity of the major bich pollen allergen Bet v 1.0101. PLoS One 9, no. 8 (2014): e104520.  

 

Deressa T, Stoecklinger A, Wallner M, Himly M, Kofler S, Hainz K, Brandstetter H, Thalhamer J, Hammerl P. Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase. PloS One 9, no. 7 (2014): e102280.  

 

Eibl C, Hessenberger M, Wenger J, Brandstetter H. Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating ist molecuar interactions. Acta Crystallogr D Biol Crystallogr. 70(PT 7): 2007-18. (2014)  

 

Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. ACS Chem Biol. ACS Chem Biol. 9(5):1113-8. (2014)  

 

Reinmuth-Selzle K, Ackaert C, Kampf CJ, Samonig M, Shiraiwa M, Kofler S, Yang H, Gadermaier G, Brandstetter H, Huber CG, Duschl A, Oostingh GJ, Pöschl U. Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitratin agents. J Proteome Res.13(3):1570-7. (2014)  

 

Dockal M, Hartmann R, Fries M, Thomassen MC, Heizmann A, Ehrlich H, Rosing J, Osterkamp F, Polakowski T, Reineke U, Griessner A, Brandstetter H, Scheiflinger F. Small peptides blocking inhibition of factor Xa and tissue factor-factor VIIa by tissue factor pathway inhibitor (TFPI). J Biol Chem. (2013)  

 

Kofler S, Ackaert C, Samonig M, Asam C, Briza P, Horejs-Hoeck J, Cabrele C, Ferreira F, Duschl A, Huber C, Brandstetter H. Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 impacts its immunological properties. J Biol Chem. 289, 540-551 (2014)  

 

Skala W, Goettig P, Brandstetter H. Do-it-yourself histidine –tagged bovine enterokinase: A handy member of the protein Engineer`s toolbox. J Biotechnol. 168, 421-425 (2013)    

to be continued...

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