Research projects

Cellular Pass Control: Antigen Processing and Presentation

The immune system recognizes both external invaders (bacteria and viruses) and internal aberrations (tumours). To this end, each cell has to identify itself towards the immune system by presenting intracellular peptides at the cell surface. Despite its enormous efficiency, some harmful cells escape the screening (pass control) of the immune system by presenting unsuspicious peptides only. We investigate the complex protease machinery involved in peptide processing. A detailed understanding promises treatment options against tumours and infectious diseases.

 

picture proteins

 

Undercover Agents – how pathogens escape cellular defence mechanisms

To undermine the defence mechanisms of the host, pathogens follow a classical strategy by imitating proteases of the host immune system. Of particular interest are bacterial collagenases which contribute to the host colonization and infiltration and thus enable host infection.

 

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

Eckhard U, Schönauer E, Nüss D & Brandstetter H (2011), Nat. Struct. Mol. Biol. 18: 1109–14

 

Barrierefreiheit: Kurzbeschreibung des Bildes

 

 

 

allergies

Allergens are foreign proteins that are per se harmless, but cause excessive immune reactions with approximately 20 % of the population, ranging from itching to anaphylactic shock. What biochemical properties render a protein allergenic? Employing structural investigations we could develop the molecular metamorphosis model that explains why (a family of) allergens elicit an allergic immune response: Triggered by intramolecular rearrangements, allergens undergo changes in oligomerization that will influence key events such as endocytosis, proteolytic processing and antigen presentation as well as antibody recognition and crosslinking. Suppression of the metamorphosis offers an innovative and highly specific therapeutic approach.

Bild von Protein

blood coagulation

The blood coagulation system stops life-threatening bleeding and at the same time prohibits similarly fatal vessel occlusion (thrombosis).  To control the underlying reactions, nature employs a molecular proofreading principle, allowing blood coagulation only when different stimuli are simultaneously present.  Failures in the fine-tuning of coagulation reactions imply bleeding disorders, e.g. haemophilia.  At the heart of the blood coagulation regulation is factor IX where we could detect long-ranged intra- and intermolecular communication lines.  These findings rationalize strategies for the treatment of bleeding disorders.

Bild von Protein

 

 

prostatic and epidermal kallikreins

Several tissue kallikreins (KLKs) are synthesised in the prostate, including KLK2, 3, 4 und 11.  These serine proteases are interconnected by an activation web.  Occurence of prostate cancer is accompanied by an exceeding increase of KLK3, aka PSA.  Therefore, the PSA level serves as a diagnostic marker of prostate cancer, albeit prone to false positive signals.  We expect to improve the diagnostic reliability by correlating the amount and the activity of all prostatic KLKs. Epidermal KLKs (KLK5, 7, 14) together with their regulator (LEKTI) play an important role in epidermal regeneration.  Disturbance of the KLK regulation generates atopic dermatitis, because a first defence barrier gets disrupted.

 

Bild von Protein
  • News
    Sharing in favor of ArMut - Helping single parents in acute financial emergencies.
    On Wednesday, the 27th of November, 2019, the University of Salzburg warmly congratulated 56 graduates who celebrated their graduations and/or completions of doctoral theses.
    Once again, the Universitätsbibliothek Salzburg will be opening the Advent 24 Windows in the Hofstallgasse and in the online Advent calendar. Texts and images may "brighten your inspiration" in time for Christmas.
    The physician and psychologist Hendrik Lehnert was solemnly introduced to his position as Rector of the Paris Lodron University Salzburg on FR 22.11.19. The new rector will be assisted by materials chemist, Nicola Hüsing; innovation expert, Katja Hutter; financial expert, Barbara Romauer; and sociologist, Martin Weichbold. Click here for Photo Gallery
    The Department of Slavonic Studies, together with the cultural center DAS KINO, would like to cordially invite you for the fourth part of the successful cinema series of the East and Central European films. The film club "Slawistyka, Slavistika, Cławistika" presents award-winning current Polish, Russian and Czech films with social and political themes.
    Prof. Otto Seppälä will hold a guest lecture on "Natural selection on immune function" at 14:00 on 13 December, 2019, in HS 434 of the Faculty of Natural Sciences, Hellbrunnerstrasse 34. The Department of Life Sciences invites you to attend!
    THEME FIELD LITERATURE: 18:00h - "Beginning in the System: Finding, Ordering, Shaping, Remembering, Speech in Rhetoric: LECTURE by Stephan Kammer (Prof. for Modern German Literature, University of Munich) // 19:15h - "The Snowball Effect: Too big to progress further", READING by Ann Cotten (author, lives in Berlin and Vienna) // wk.sbg.ac.at/figurationen-des-uebergangs
  • Veranstaltungen
  • 11.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    11.12.19 SOZIALE WÄRME oder die Freude an der Neugierde
    11.12.19 Veranstaltungsreihe "Sozialpädagogische Blicke" 2019/20
    12.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    12.12.19 Loop models on a fractal
    12.12.19 Salzburger Museen und Sammlungen Geschichte vor Ort. Wie kommt das Objekt ins Netz? Salzburger Regionalmuseen, Inventarisierung Kulturgüterdatenbank
    12.12.19 Figurationen und Szenen des Beginnens: Themenfeld LITERATUR
    12.12.19 Salzburger Juristische Gesellschaft
    13.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    13.12.19 Natural selection on immune function
    14.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    15.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    16.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
    16.12.19 Ukraine – Moskau – Konstantinopel
    17.12.19 Lichtvolle Impulse in der vorweihnachtlichen Zeit
  • Alumni Club
  • PRESS
  • Uni-Shop
  • University of Salzburg's facebook site University of Salzburg's twitter site University of Salzburg's instagram site University of Salzburg's flickr site University of Salzburg's vimeo site