Molecular Cancer Research & Tumor Immunology

Oncogenic Signaling and the Tumor Immune-Environment

Despite considerable progress in the fight against cancer, malignant diseases are becoming a global pandemic. More than 14 million new cases were diagnosed in 2012 and about 8 million people died of cancer worldwide. The global cancer burden is projected to reach more than 21 million new cases and 13 million deaths per year by 2030. The socioeconomic toll of cancer is also alarming; premature death and disability account for yearly economic losses of about USD 1 trillion. The development of innovative and more efficient therapies is a major challenge for biomedical research of the 21st century.

Understanding the intricate molecular and genetic networks regulating cancer growth, metastasis and drug resistance is key to the development of better therapies.

The main focus of the lab is on oncogenic pathways such as Hedgehog/GLI signaling, their cooperation in tumor-initiating metastatic cancer stem cells (CSC) and their role in suppressing the anti-tumoral response of the immune system. Eradicating cancer by targeted and rational combination treatments including immunotherapy approaches is a prime focus of the lab.

 

Barrierefreiheit: Kurzbeschreibung des Bildes

Figure 1: Cancer stem cells and the tumor microenvironment. Vivid signal cross-talk between cancer cells, rare tumor initiating cancer stem cells (CSC) and the microenvironment drives cancer growth and metastasis. Understanding the molecular basis of these molecular communication processes will open up new opportunities for innovative therapies based on rational multimodal combination treatments

To advance cancer research and therapy in the Salzburg area, the Aberger group together with the Salzburg Cancer Research Institute at the University Clinics Salzburg (SALK/PMU) founded the  “Cancer Cluster Salzburg“ (CCS). CCS constitutes a research network of 16 expert groups in basic, translational and clinical cancer research to explore new cancer-driving mechanisms and develop innovative treatments with improved therapeutic efficacy (for details see: www.cancercluster-salzburg.at).

The research group is a member of the international PhD Program "Immunity in Cancer and Allergy" from the FWF,  member of the doctoral school PLUS "Biomolecules" and a member of the "Allergy-Cancer-BioNano Research Centre" from the University of Salzburg.

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    With the PLUS Talk, a new form of communication was introduced to the Paris Lodron University of Salzburg in 2020. Within the framework of this format members of the rectorate discuss certain key issues with employees of the PLUS, students and public representatives. The discussions take place LIVE and offer participants the opportunity to ask questions on current topics.
    On Wednesday 17th March 2021 PLUS is holding a virtual open day and warmly invites all interested pupils and final year classes offenen. Further information can be found under www.uni-salzburg.at/openday.
    After talks with the ministry and intensive consultation with the deans, the rectorate of the Paris Lodron University of Salzburg has decided that exams should generally only be conducted online at the moment. The following points apply here:
    There are numerous challenges in everyday elementary education, not only in Corona times. The art lies in dealing constructively with challenging situations. The fourth day of elementary education in Salzburg on 22nd January 2021, which will take place in digital form due to the pandemic-related measures, is dedicated to the topic of "Dealing with challenges in a solution-oriented way - competently and safely".
    Dialogue and Liberation in a Digital Future - Place and time: Paris Lodron University Salzburg; 14-16 October 2021 - Contact: markus.maier@stud.sbg.ac.at
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    INTERDISCIPLINARY CONGRESS under the leadership of Reinhard Heinisch, Reinhard Klaushofer, Christoph Kühberger and Margit Reiter
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    As part of the series „MUSIC & MEDICINE“ the cooperation focus group science and art is organising another online lecture on the 27th January 2021.
    10 am /Online-Matinee with lecture and discussion „Artes“ series with Robert Brennan and Wolf-Dietrich Löhr.
    As part of the series „MUSIC & MEDICINE“ the cooperation focus group science and culture is organising another online lecture on the 3rd February 2021.
    The Law Academy at the University of Salzburg is offering three online seminars in January 2021 on the topics of an update to competition law (antitrust law and UWG) on Friday, 15 January 2021, an update to company law on Friday, 22 January 2021 and an update to warranty law on Friday, 29th January 2021.
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