Molecular Cancer Research & Tumor Immunology

Oncogenic Signaling and the Tumor Immune-Environment

Despite considerable progress in the fight against cancer, malignant diseases are becoming a global pandemic. More than 14 million new cases were diagnosed in 2012 and about 8 million people died of cancer worldwide. The global cancer burden is projected to reach more than 21 million new cases and 13 million deaths per year by 2030. The socioeconomic toll of cancer is also alarming; premature death and disability account for yearly economic losses of about USD 1 trillion. The development of innovative and more efficient therapies is a major challenge for biomedical research of the 21st century.

Understanding the intricate molecular and genetic networks regulating cancer growth, metastasis and drug resistance is key to the development of better therapies.

The main focus of the lab is on oncogenic pathways such as Hedgehog/GLI signaling, their cooperation in tumor-initiating metastatic cancer stem cells (CSC) and their role in suppressing the anti-tumoral response of the immune system. Eradicating cancer by targeted and rational combination treatments including immunotherapy approaches is a prime focus of the lab.

 

Barrierefreiheit: Kurzbeschreibung des Bildes

Figure 1: Cancer stem cells and the tumor microenvironment. Vivid signal cross-talk between cancer cells, rare tumor initiating cancer stem cells (CSC) and the microenvironment drives cancer growth and metastasis. Understanding the molecular basis of these molecular communication processes will open up new opportunities for innovative therapies based on rational multimodal combination treatments

To advance cancer research and therapy in the Salzburg area, the Aberger group together with the Salzburg Cancer Research Institute at the University Clinics Salzburg (SALK/PMU) founded the  “Cancer Cluster Salzburg“ (CCS). CCS constitutes a research network of 16 expert groups in basic, translational and clinical cancer research to explore new cancer-driving mechanisms and develop innovative treatments with improved therapeutic efficacy (for details see: www.cancercluster-salzburg.at).

The research group is a member of the international PhD Program "Immunity in Cancer and Allergy" from the FWF,  member of the doctoral school PLUS "Biomolecules" and a member of the "Allergy-Cancer-BioNano Research Centre" from the University of Salzburg.

  • News
    Never before have so many forensic patients been accommodated in Austria as of the effective date of 1st October 2020. Relief from the enforcement of the measures and also the treatment of seriously abnormal lawbreakers, is urgently required and unavoidable.
    Digitization has led to an enormous spread of different forms of mobile working. Corona has brought an additional boost and has introduced home office in areas and for activities that were previously unimaginable.
    The virtual international conference „The Mediality of the Letter – diplomatic Correspondence in the Context of Early Modern Letter Culture ” will take place via Webex on 29th/30th/31st October.
    In social pedagogical practice employees (agents) are confronted with a variety of challenges in complex, open social problem situations that have to be dealt with "professionally“ and with „ qualitatively“.
    As part of a six year long laser scan-monitoring in the Hohen Tauern geoscientists from Austria, Germany and Switzerland (GEORESEARCH, University of Salzburg, TU Munich, University of Bonn, University of Lausanne) examined the connection between the current glacier retreat and rockfall activity.
    New publication from the der MINT and the Media Didactics of the University of Salzburg by Waxmann Verlag.
    The Faculty of Slavic Studies, the cultural centre DAS KINO and the Russian Centre invite you to the fifth series of cinema films from Eastern and Central Europe. As part of the film club „Slawistyka, Slavistika, Cлавистика“ award winning current Polish, Russian and Czech films with political and social themes will be shown.
    Applications for two dissertation prizes (worth 2,000 euros each) can be made until the 31st October.
    The Language Center has been active in the field of intercomprehension didactics for almost 20 years,Well-known multilingual didactics experts, came together to present the current state of research in this area.The result is the anthology "Lehr- und Lernkompetenzen für die Interkompehension. Perspektiven für die mehrsprachige Bildung (Teaching and Learning Skills for Intercomprehension. Perspectives for Multilingual Education)"Band 10 der Salzburger Reihe zur Lehrer/innen/bildung.
    During the time of Corona, in particular, it became clear just how important it is to support students digitally in their every day university life. The project „On Track“ – stay on track combines digital and social worlds. It is starting at the right time!
  • Veranstaltungen
  • 04.11.20 PLUS startupSPRECHTAG - gather your ideas
  • Alumni Club
  • PRESS
  • University of Salzburg's facebook site University of Salzburg's twitter site University of Salzburg's instagram site University of Salzburg's flickr site University of Salzburg's vimeo site