AG Stoiber 

Animal structure and development

Several lines of research are pursued by our team.

 

NETosis (Stoiber, Obermayer)

In this scientific area, we are interested in the pathogen-host interaction. The research is increasingly focused on neutrophil extracellular traps (NETs) since these webs of extruded DNA were identified as important elements of innate immune response. Being decorated with cytotoxic proteins, NETs act in a fragile balance between antimicrobial defence and fatal host tissue damage, with most important implications for the pathogenesis of chronic inflammatory disease and acute organ failure. The main pathway of NET generation (NETosis) by neutrophils is a special form of cell death mediated by molecular signals, for example by the chemokine CXCL8/IL-8. It involves the generation of reactive oxygen species (ROS) and histone protein citrullination. A second type of NETosis has been shown to leave neutrophils viable and phagocytotic active.

Our research group has over the years gained a high degree of expertise in analysing the microstructure and pathogenic potential of NETs. Combining electron microscopy (TEM, SEM) with immunolabelling, in situ hybridisation and other advanced histology techniques, we have made significant contributions to clarify the maturation of NET-forming ability in neonates and to test CXC receptor antagonists as a possible means of therapeutic intervention. Impressive evidence has been collected that NETs decisively contribute to chronic inflammation in the periodontium and especially in the airways during cystic fibrosis and chronic obstructive pulmonary disease (COPD), and that NETosis involves chromatin decondensation to beads-on-a-string fibres.

The work has entailed fruitful collaborations with internationally renowned research groups (presently at PMU Salzburg, Saarland University, University of Tübingen). The potential benefit of this research is expanding. Entangled with respiratory burst and autoantibody induction, NETs are turning out be almost omnipresent in inflammatory response, playing important roles in rheumatoid arthritis just as for the osseointegration of titanium implants.  

 

 

Developmental biology (Steinbacher, Stoiber)

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Over the last two decades, teleost fish have gained a high profile as suitable model organisms for developmental biology, especially for study of the spatial patterns and causal mechanisms of vertebrate organ formation and cell differentiation. This research has many important implications, extending from the formation of complex structures and functions through individual ontogeny and over evolutionary time to aspects of human disease. Our specific interest is focused on the development and growth of skeletal muscle and its plasticity in response to external factors and interspecific variation. We have identified the fish dermomyotome, a transient structure of the somite that provides most of the muscle precursor cells in the embryo, and have shown how such cells enter the myotome. Recent work demonstrates that the proliferation-differentiation balance of these stem cells is dependent upon environmental factors, with important downstream effects on fish growth in later life. A particular focus has been put on the formation of hypaxial and fin muscles, the fish homologues of terrestrial vertebrate limb, tongue, laryngeal and diaphragma muscles.  

 

 

Muscle degradation (Pittner, Steinbacher)

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Estimation of the time since death is a crucial aspect in forensic science. This is necessary to gain crucial information about the circumstances of death and is, in criminal cases, essential for the confirmation or invalidation of alibis and ultimately for the solution of a crime. Several methods are used to delimitate the post mortem interval (PMI) in every day forensic work, such as the temperature method which is based on the decrease of the body core temperature from 37°C. However, this method is only useful in the early postmortem phase (until up to two days postmortem). Forensic entomology which analyses the presence of cadaver feeding insects and their developmental stages requires accessibility of the body to such insects and was shown to deliver valuable information only for minimal PMI values. Thus, additional methods to delimitate the time since death are required that produce reliable information in a minimum of time and can easily be implemented in any forensic laboratory. Our previous results demonstrate that muscle proteins degrade in a predictable fashion after death. Analyses of the presence and absence of these proteins and their split products using molecular biological methods (Western blotting, zymography) allows to draw relatively precise conclusions about the time of death. Our current work is aimed to identify a large number of muscle proteins in humans and pigs which can be used for delimitation of the time since death. In addition, the influence of internal and external factors (such as temperature, age, gender, body mass index, etc.) on post mortem degradation behaviour of these proteins will be evaluated. The results of this work are aimed to build the foundation for establishment of this method in forensic laboratories. The collected data will be used to establish a database which can be used by forensic examiners from all over the world to delimitate the time since death.  

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Fish biology and herpetology (Schabetsberger)

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Our team maintains a broad interest in zoology, working in freshwater, marine, and terrestrial habitats in tropical and temperate environments.

Currently, the primary focus is on tropical freshwater lakes in Madagascar and on South Pacific islands using these isolated water bodies as model ecosystems for the study of biodiversity, global change, deforestation and the effects of introduced alien predators. In collaboration with many taxonomists, we assess species diversity from algae to fish and relate it to environmental conditions.

Out of these projects we initiated research on freshwater eels (Genus Anguilla) in Oceania. We use pop-up satellite transmitters to follow their long distance marine migrations to the spawning areas. Together with oceanographers and geneticists we try to understand oceanographic conditions and population structure.

In close collaboration with the Austrian Federal Agency of Water Management we are working on various aspects of limnology and fisheries in Austrian alpine lakes. Recent projects have been centered on trophic interactions in lake food webs and on the control of introduced predators and their parasites.

We are also studying population biology and ecology of amphibians in alpine environments. We have covered a broad range of topics from feeding ecology, sex determination to the use of telemetry for delineation of terrestrial reserves.  



Insect Biology (Haslett)

The research interests of this team are multidisciplinary, covering a spectrum of the biophysical and now also the social sciences, at local to pan-European scales. However, a general interest in classical zoology and insect biology has been maintained, primarily involving flower-visiting Diptera and Hymenoptera, but also covering other insect groups. Particularly, present research includes taxonomy and functional biodiversity of syrphid flies along altitudinal gradients and under different land uses in the Austrian Alps, and occurrence of potential pollinating insects (wild bees, syrphid flies) in a garden landscape in Salzburg. Activities in biodiversity and conservation research expand upon this to cover more general principles, such as the development and implementation of a European Strategy for the Conservation of Invertebrates for the Council of Europe under the Bern Convention, integrating policy and management in Protected Areas and biodiversity protection in relation to the provision of Ecosystem Services (everything that nature provides that is of benefit to humans) and integration into sectoral policy.

Further active research focuses on the provision of Ecosystem Services under dynamic conditions of environmental change, including climate change, and understanding the consequences of possible extreme climate change (greater than the present 2°C warming target) for decision-making across Europe. These are contributions to international EU research projects: The FP7 BESAFE project focuses on improving our understanding of alternative ways in which the “value of biodiversity” can be used to improve policy-making and governance at local to European and global scales (www.BESAFE-project.net). The FP7 Project IMPRESSIONS (www.impressions-project.eu) has the general aim to advance understanding of the consequences of high-end climate and socio-economic scenarios and to evaluate how such knowledge can be embedded within effective and integrated adaptation and mitigation decision-making processes. These projects have also ensured close co-operation with a large number of high level research institutions across Europe and globally.      

  • News
    Das Paper "The disabling effect of enabling social policies on organizational career management" von Astrid Reichel (Professorin für Human Resource Management an der PLUS) et al. wurde beim Academy of Management Meeting 2019, der mit über 10.000 TeilnehmerInnen weltweit größten und wichtigsten Management Konferenz, mit dem Emerald Best International Symposium Award ausgezeichnet.
    Univ.Doz. Dr. Dr.h.c. Jasmine Dum-Tragut erhielt die Medaille am 31. Oktober im Rahmen der Schlussveranstaltung der von ihr kuratierten Ausstellung "Fernab der Heimat - in der Heimat Schicksale armenischer Kriegsgefangener im Ersten Weltkrieg" am Genozid-Museum-Institut in Jerevan/Armenien.
    Die Salzburger Historikerin Christina Antenhofer wurde kürzlich zum Mitglied der Europäischen Akademie der Wissenschaften und Künste (Historische Klasse) ernannt.
    Zum Windersemester 2019/20 berief die Universität Salzburg fünf neue UniversitätsprofessorInnen: Michael BLAUBERGER, Politik der Europäischen Union, Politikwissenschaft und Soziologie (+ DZ SCEUS), Alexander SOKOLICEK, Klassische Archäologie, Altertumswissenschaften, Ulrike GREINER, Professionsforschung und LehrerInnenbildung unter besonderer Berücksichtigung der Fachdidaktiken, School of Education, Margit REITER, Europäische Zeitgeschichte.
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    Vom 5. bis 22. November 2019 lädt Südwind in Zusammenarbeit mit der Universität Salzburg ExpertInnen zum Thema globale Ungleichheiten ein und bietet ein vielfältiges Programm: 13 Veranstaltungen der Reihe "REDUCE INEQUALITIES global denken - nachhaltig handeln" setzen sich aus verschiedenen Perspektiven mit globalen Fragen und deren Wechselwirkung mit der lokalen und individuellen Ebene auseinander.
    Eine internationale Tagung, 13.–15. November 2019, veranstaltet von SALZBURG MUSEUM und UNIVERSITÄT SALZBURG, Tagungsleitung: Univ.-Prof. Dr. Christoph Kühberger
    Am: 14.11.2019 // Zeit: 18:30h s.t. - 20:00h // Ort: Hörsaal 207 der Rechtswiss. Fakultät der Universität Salzburg // Churfürststraße 1 // A-5020 Salzburg // (Zugang beschildert)
    Priv.-Doz. Dr. Matthias Kropf hält am 15. November 2019 um 14 Uhr im HS 421 der Naturwissenschaftlichen Fakultät, Hellbrunnerstrasse 34, einen Gastvortrag zum Thema "Phylogeographical Studies of selected Steppe Plants in the Pannonian and Western Pontic Region". Der Fachbereich Biowissenschaften lädt herzlich dazu ein!
    Margit Reiter, seit WS 2019 neue Professorin für Europäische Zeitgeschichte am Fachbereich Geschichte präsentiert am 20. November ihr neues Buch "Die Ehemaligen" im HS 381, GesWi, Rudolfskai 42.
    DONNERSTAG, 21.11.: VORTRÄGE (8.30-19.00h) bei Wissenschaft & Kunst, Bergstr. 12a, KunstQuartier, Atelier 1.OG // FREITAG, 22.11.: EXKURSION (8.30-16.00h) Gedenkstätte Konzentrationslager Ebensee, Gedenkstätte Mauthausen. Abfahrt: 8.30 Uhr Unipark Nonntal, Erzabt-Klotz-Straße 1
    Die jährlich stattfindende interdisziplinäre Fachtagung des Wissensnetzwerks Recht, Wirtschaft und Arbeitswelt findet dieses Jahr am Donnerstag, 21.11.2019, zum Thema "Die Arbeit ist immer und überall - Mobiles Arbeiten und seine Folgen" auf der Edmundsburg statt.
    Der FB KoWi lädt Sie sehr herzlich zum Gastvortrag zum Thema How News Use is Changing Across the World - Vortrag von Dr. Richard Fletcher – Reuters Institute, University of Oxford .
    Im Rahmen der Vortragsreihe Geschichte im Gespräch sowie der Vorlesung "Grundlagen der Mittelalterlichen Geschichte (Christina Antenhofer)" hält Thorsten Hiltmann (Münster) am 26. November 2019 um 09 Uhr im HS 380 einen Vortrag zum Thema Mittelalterliche Heraldik zwischen Kulturgeschichte und neuen digitalen Methoden
    Der Fachbereich Slawistik möchte Sie zusammen mit dem Kulturzentrum DAS KINO sehr herzlich zum vierten Teil unserer erfolgreichen Kinoreihe der ost- und mittelosteuropäischen Filme einladen. Im Rahmen des Filmklubs „Slawistyka, Slavistika, Cлавистика“ werden preisgekrönte aktuelle polnische, russische und tschechische Filme mit gesellschaftlicher und politischer Thematik gezeigt.
    28. bis 30. November 2019 - Unipark Nonntal, Erzabt-Klotz-Straße 1, 5020 Salzburg, Abteilung Musik- und Tanzwissenschaft, Tanzstudio, Raum 2.105, 2. OG
    Der Fachbereich Linguistik lädt alle Interessierten ein zur Teilnahme an der 45. Österreichische Linguistiktagung. Die Veranstaltung findet am 6. und 7.12.19 im Unipark Nonntal statt. Die Frist zur Registrierung zu den regulären Teilnahmegebühren in Höhe von 40 bzw. 15 Euro (für Studierende und taube TeilnehmerInnen) wurde bis zum 07.11.2019 verlängert.
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  • 13.11.19 Bestsellerautor Bernhard Aichner präsentiert seinen neuesten Thriller „DER FUND“
    14.11.19 Symposion "Wirtschaftliche Betrachtungsweise"
    14.11.19 Maibaum 4.0 – Unsere kulturelle Zukunft am Land
    14.11.19 Salzburger Museen und Sammlungen - Geschichte vor Ort. Geschichtsforschung und Geschichtsdarstellung im Salzburger Freilichtmuseum. Von einer Hausübertragung bis zur Dokumentation des frühen ländlichen Fremdenverkehrs in Salzburg
    14.11.19 Salzburger Juristische Gesellschaft
    14.11.19 Group Singing: Positive Intervention in the Lives of People with Parkinson’s / Positive Auswirkungen des Chorgesangs auf Patientinnen und Patienten mit Parkinson
    15.11.19 Symposion "Wirtschaftliche Betrachtungsweise"
    15.11.19 Group Singing: Positive Intervention in the Lives of People with Parkinson’s / Positive Auswirkungen des Chorgesangs auf Patientinnen und Patienten mit Parkinson
    15.11.19 Phylogeographical studies of selected steppe plants in the Pannonian and Western Pontic region
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