LIST OF PUBLICATIONS

(last update: 03/2019)

 

 

PUBLICATIONS HOREJS-HOECK (peer reviewed)

Total number of scientific publications: 42

Overall number of citations: >2245

Average citations per item: >53

Hirsch-index: 23

 

Binder S, Luciano M, Horejs-Hoeck J. The Cytokine Network in Acute Myeloid Leukemia (AML): A Focus on Pro- and Anti-Inflammatory Mediators, Cytokine and Growth Factor reviews, 2018

Michelini S., Sarajlic M., Duschl A. and Horejs-Hoeck J. Dendritic cell activation and feedback inhibition in sterile and non-sterile inflammation, Hum Immunol. 2018 Aug;79(8):610-615. doi: 10.1016/j.humimm.2018.06.002

Aglas L., Gilles S., Bauer R., Huber S., Araujo GR., Mueller G., Scheiblhofer S. , Amisi M.,, Dang HH, Briza P., Bohle B., Horejs-Hoeck J., Traidl-Hoffmann C, Ferreira F. Context matters: Th2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity, J Allergy Clin Immunol. 2018 May 18. pii: S0091-6749(18)30711-5. doi: 10.1016/j.jaci.2018.05.004.

Strasser L., Schwarz H, Dang H.-H., Asam C., Ferreira F., Horejs-Hoeck J., Huber C.G. Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells, 2017 Sci Rep.Nov 30;7(1):16638. doi: 10.1038/s41598-017-16726-2

Li Y., Zhenzhen S., Radauer-Preiml I., Ancuela A., Casals E., Luetz-Meindl U., Cobal M., Zhoumeng L., Jaberi-Douraki M., Italiani P., Horejs-Hoeck J., Himly M., Monteiro-Riviere NA., Duschl A., Puntes V., Boraschi D. Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation, 2017 Nanotoxicology. Nov - Dec;11(9-10):1157-1175. doi: 10.1080/17435390

Neuper T., Ellwanger K., Schwarz H., Kufer TA., Duschl A., Horejs-Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells, 2017, Sci Rep. Apr 21;7(1):1005. doi: 10.1038/s41598-017-00691-x.

Schwarz H, Gornicec J, Neuper T, Parigiani MA, Wallner M, Duschl A, Horejs-Hoeck J. Biological Activity of Masked Endotoxin. Sci Rep. 2017 Mar 20;7:44750. doi: 10.1038/srep44750.

Radauer-Preiml I, Andosch A, Hawranek T, Luetz-Meindl U, Wiederstein M, Horejs-Hoeck J, Himly M, Boyles M, Duschl A. Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses. Part Fibre Toxicol. 2016 Jan 16;13:3. doi: 10.1186/s12989-016-0113-0.

Steiner M., Hawranek T., Schneider M., Harrer A., Horejs-Hoeck J., Ferreira F., Himly M. Elevated Toll-like receptor-induced CXCL8 secretion in human blood basophils from allergic donors is independent of Toll-like receptor expression levels, 2016, PLoS One. Feb 12;11(2):e0149275. doi: 10.1371/journal.pone.0149275

Maier E, Mittermeir M, Ess S, Neuper T, Schmiedlechner A, Duschl A, Horejs-Hoeck J. Prerequisites for Functional Interleukin 31 Signaling and Its Feedback Regulation by Suppressor of Cytokine Signaling 3 (SOCS3). J Biol Chem. 2015 Oct 9;290(41):24747-59. doi: 10.1074/jbc.M115.661306.

Machado Y., Freier R., Scheiblhofer S., Thalhamer T., Mayr M., Briza P., Grutsch S.,Ahammer L., Fuchs J., Wallnöfer H., Isakovic A., Kohlbauer V., Hinterholzer A., Steiner M., Danzer M., Horejs-Hoeck J., Ferreira F., Liedl KR., Tollinger M., Lackner P., Johnson CM., Brandstetter H., Thalhamer J., Weiss R. Fold-stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen, 2015, J Allergy Clin Immunol. Nov 7. pii: S0091-6749(15)01366-4. doi: 10.1016/j.jaci.2015.09.026

Schwarz H, Schmittner M, Duschl A, Horejs-Hoeck J. Residual endotoxin contaminations in recombinant proteins are sufficient to activate human CD1c+ dendritic cells. PLoS One. 2014 Dec 5;9(12):e113840. doi: 10.1371/journal.pone.0113840.

Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, Asam C, von Grafenstein S, Fuchs JE, Briza P, Liedl KR, Bohle B, Ferreira F, Brandstetter H, Oostingh GJ, Duschl A. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101. PLoS One. 2014 Aug 15;9(8):e104520. doi: 10.1371/journal.pone.0104520.

Maier E., Werner D., Duschl A, Bohle B., Horejs-Hoeck J. Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way. 2014, J Immunol. 2014 Jul 15;193(2):645-54. doi: 10.4049/jimmunol.1301836.

Kofler S., Ackaert C., Samonig M., Asam C., Briza P., Horejs-Hoeck J., Cabrele, Ch., Ferreira F., Duschl A., Huber C., Brandstetter H. Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties, 2014, J. Biol Chem, Jan 3;289(1):540-51

Schwarz H, Posselt G, Wurm P, Ulbing M, Duschl A, Horejs-Hoeck J. TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2. 2013. Immunobiology. Apr;218(4):533-42

Horejs-Hoeck J, Schwarz H, Lamprecht S, Maier E, Hainzl S, Schmittner M, Posselt G, Stoecklinger A, Hawranek T, Duschl A. Dendritic cells activated by interferon-γ/STAT1 express interleukin-31 receptor and release proinflammatory mediators upon interleukin-31 treatment. 2012 J Immunol, 188:5319-26

Posselt G, Schwarz H, Duschl A, Horejs-Hoeck J. Suppressor of Cytokine Signalling 2 (SOCS2) is a feedback inhibitor of TLR induced activation in monocyte derived dendritic cells. 2011. J. Immunol., 187:2875-84

Maier E, Hebenstreit D, Posselt G, Hammerl P, Duschl A, Horejs-Hoeck J. Inhibition of suppressive T Cell Factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL- 4/STAT6 signaling. 2010 J. Biol. Chem. 286:919-928.

Dubrac S, Elentner A, Ebner S, Horejs-Hoeck J, Schmuth M. Modulation of T lymphocyte function by the pregnane X receptor. 2010. J Immunol. 184:2949-57

Hebenstreit D, Giaisi M, Treiber MK, Zhang X-B, Mi H-F, Horejs-Hoeck J, Andersen KG, Krammer PH, Duschl A, Li-Weber M. Lef-1 negatively controls Interleukin-4 expression through a proximal promoter regulatory element. 2008. J. Biol. Chem. 283:22490-7.

Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A. Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione. 2008. Env. Tox., 23:84-95.

Horejs-Hoeck J., Wirnsberger G., Hebenstreit D., Posselt G., Duschl A. Interleukin-4 regulates the expression of Thymus - and Activation-Regulated Chemokine (TARC) /CCL17 by a Signal Transducer and Activator of Transcription 6 (STAT6) - dependent mechanism. Allergy & Clinical Immunology International – Journal of the World Allergy Organization ,Proc. 26th Symp. Coll. Int. Allergol. Holgate, S. Marone, G, Ring J, (Eds.) Hogrefe & Huber, Cambridge MA, 2007, pp. 308-312.

Maier E., Wirnsberger G., Horejs-Hoeck J., Duschl A., Hebenstreit D. Identification of a distal tandem STAT6 element within the CCL17 locus. 2007 Hum Immunol. Dec; 68(12):986-92.

Battaglia M., Stabilini A., Migliavacca B., Horejs-Hoeck J., Kaupper T., Roncarolo M.G. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 2006 Dec; 177:8338-8347.

Wirnsberger G, Horejs-Hoeck J, Posselt G, Hebenstreit D, Duschl A. IL-4 induces expression of the CC chemokine ligand TARC/CCL17 in human T cells by two functional STAT6-binding motifs located upstream of the transcription initiation site. Eur. J. Immunol. 2006 Jul; 36:1882-1891.

Horejs-Hoeck J., Hren, A, Mudde GC, Woisetschläger M. Inhibition of immunoglobulin-E synthesis through FcγRII (CD32) by a mechanism independent of B-cell receptor co-crosslinking. Immunology, 2005 Jul;115(3):407-15.

Hebenstreit, D., Luft, P., Schmiedlechner, A., Duschl, A., Horejs-Hoeck, J. SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells. Mol Immunol., 2005 Feb; 42(3):295-303

Gounni AS., Q. Hamid, SM. Rahman, L. Liu, Horejs-Hoeck J. Yang J.. Expression of functional Interleukin-9 Receptor by human airway smooth muscle cells. J. Immunol. 2004 Aug; 15;173:2771-2779

Hebenstreit, D., Luft, P., Schmiedlechner, A., Regl, G., Frischauf, A.-M., Aberger, F., Duschl, A., Horejs Hoeck, J. IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6 binding motifs located upstream of the transcription initiation site. J. Immunol., 2003 Dec; 171, 5901-5907

Bömmel H., Haake M., Luft P., Horejs-Hoeck J., Hein H., Bartels J., Schauer C., Pöschl U., Kracht M. Duschl A. The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin, Int.Immunopharm. 2003 Oct; 3, 1371-1379

Hoeck J., Woisetschläger M. Activation of Eotaxin-3/CCL26 Gene expression in human dermal fibroblasts is mediated by STAT6.J. Immunol. 2001 Sept.15;167:3216-3222.

Stütz AM., Hoeck J., Natt F., Cuenoud B., Woisetschläger M. Inhibition of Interleukin-4 and CD40-induced IgE germline gene promoter actitivity by 2’-aminoethoxymodified Triplex-forming oligonucleotides. J. Biol.Chem. 2001 Apr; 13; 27 (15):11759-65

Hoeck J., Woisetschläger M. STAT6 Mediates Eotaxin-1 Expression in IL-4 or TNF-alpha-Induced Fibroblasts. J.Immunol. 2001 Apr; 1;166(7):4507-15.

 

 

REVIEW ARTICLES

Binder S, Luciano M, Horejs-Hoeck J. The Cytokine Network in Acute Myeloid Leukemia (AML): A Focus on Pro- and Anti-Inflammatory Mediators, Cytokine and Growth Factor reviews, 2018

Maier E, Duschl A, Horejs-Hoeck J. STAT6-dependent and -independent mechanisms in Th2 polarization. Eur J Immunol. 2012 42:2827-33 (“Paper of the Month”, January 2013, Fachbereich Molekulare Biologie and one of the most accessed EJI-articles from October to December 2012).

Hebenstreit, D., Wirnsberger, G., Horejs-Hoeck, J., Duschl, A. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev. 2006 June, 17:173-88.

Hebenstreit, D., Horejs-Hoeck, J., Duschl, A. Jak-STAT dependent gene regulation by cytokine signaling. Drug News Perspect. 2005 May; 18 (99):421.

Nelde, A., Hebenstreit D., Schmiedlechner, A., Horejs-Höck, J., Duschl, A.. Inhibition of IL-4Ralpha or STAT6 as experimental strategies for the therapy of atopic diseases. Allergy Frontiers and Futures. Proc. 24h Symp. Coll. Int. Allergol. J.B.

Bienenstock, J. Ring, A.G.T. Togias (Eds.), Hogrefe & Huber, Cambridge MA, 2004, pp. 317-319. Horejs-Hoeck J., Duschl A. Die Rolle von Zytokinen bei Allergien und Asthma Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 2003.46:211-216

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