The functional integrity of the human epithelium is crucially important for the protection against intruding pathogens. The cell-adhesion molecule and signaling protein E-cadherin plays a central role in the establishment and maintenance of the epithelial barrier function. We identified a novel bacterial mechanism how bacterial pathogens can efficiently disrupt the epithelial lining through cleavage of the ectodomain of E-cadherin by the secreted bacterial serine protease HtrA (high temperature requirement A). Most research was performed with HtrA expressed by Gram-negative bacteria; however, Gram-positive pathogens express a structurally different class of HtrA proteins. Our preliminary data show that the regulation and functions of HtrA differ considerably between Gram-positive and Gram-negative pathogens while the involved mechanisms are completely unclear. Here, we investigate (i) the activation and substrate specificity of HtrA proteases expressed by selected Gram-positive pathogens and (ii) the functional role of HtrA and E-cadherin truncation in the infection process.


Important publications:

  • Abfalter et al., 2019, BMC Microbiol
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    The Austrian Academy of Sciences has awarded Mag. Dr. Daniel Ehrmann, university assistant and doctoral candidate in the Department of German Studies, four year APART-Grant, which he will start on the1. 3. 2021.During this time he will complete his post doctoral thesis project „Aggregation. Relationaliity and the Constellations of Literature (1650 – 1950). Toward a medium range historical model.
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