Barrierefreiheit: Kurzbeschreibung des Bildes

Miox-genes are transiently expressed during development. The four stages of a flower development show the changing expression pattern visualized with the GUS reporter gene.

Myo-Inositol Oxygenase

The enzyme myo-inositol oxygenase (MIOX) represents a unique enzyme catalyzing the ring cleavage of myo-inositol into glucuronic acid. The enzyme serves at least two purposes:

1) conversion of inositol into glucuronic acid to synthesize UDP-glucuronic acid as cell wall precursor

2) degradation of inositol (mainly in animals). It is a precursor for vitamin C in animals and possibly in plants

Arabidopsis has 4 isoforms of MIOX. A quadruple knockout in all 4 genes, obtained by several rounds of crossing, is viable, indicating that plants do not need this pathway under standard growth conditions (Endres, S. and Tenhaken, R. (2011).

It is very interesting to see that knockout mutants in at least two of the four MIOX genes leads to plants, which exhibit a high nematode tolerance. The plants are otherwise normal (Siddique et al. (2009) New Phytol. 184: 457-72). This finding was recently patented by Holger Bohlmann (Boku University, Vienna) and our group. It may lead to the further discovery of a novel type of nematode resistance and broadens the spectrum of methods to fight this group of serious plant diseases.