Mechanism of drug-induced Anaphylaxis

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely distributed and frequently prescribed as mild analgesics and antipyretics for various types of pain. Systemic hypersensitivity reactions to NSAIDs represent one type of possible adverse drug reactions, but may have potentially life-threatening consequences. Notably, the mechanism of hypersensitivity reactions often remains unclear due to the lack of appropriate diagnostic means, and a differentiation between allergic and pseudoallergic adverse reaction can not be made unequivocally. We will investigate the mechanism of systemic hypersensitivity to the NSAID diclofenac. We will investigate the immune interactions of diclofenac by histamine release and human serology. Metabolites will be tested in addition to diclofenac and alternative means of conjugating diclofenac to human serum albumin will be investigated. We aim to develop an in vitro diagnostic test system and assess its clinical applicability in collaboration with two major allergy centers in Austria. As mouse models have repeatedly proven to be versatile instruments in allergy research, we will use immunization protocols capable of inducing an immune response resembling the in vivo situation in humans for the establishment of a mouse model for diclofenac allergy. We will furthermore apply proteomic methods to identify serum proteins being haptenized by diclofenac and study novel immune interactions.

Project leader: Martin Himly, PhD
Project number: P18820-B13
Project type: § 26 project funded by the Austrian Research Fund (FWF)
Run time: July 1st, 2006 – June 30th, 2011
Short title: Mechanism of drug-induced anaphylaxis
Staff: Andrea Harrer (PhD student),
Markus Steiner (PhD student),

  • ENGLISH English
  • News
    Das Wissen für morgen schon heute erleben – mit diesem Ziel erarbeiten universitäre und außeruniversitäre Forschungseinrichtungen in der Science City Itzling neue Vermittlungsformate.
    Mo. 19.11.2018, 17.15 Uhr, HS E.001 (Unipark) - ao. Univ.-Prof. Dr. Agnethe Siquans (Wien) - Kirchenväter und Judentum
    Herr Dr. Sven Th. Schipporeit (Institut für Klassische Archäologie, Universität Wien) hält zu diesem Thema am Mi, 21. November 2018, 18.30 Uhr, in der Abgusssammlungs SR E.33, Residenzplatz 1, einen Vortrag
    Vortrag von Prof. Dr. Samuel Mössner, WWU Münster, am Mittwoch, 21.11.2018 um 18h im HS 436, Naturwissenschaftliche Fakultät
    Sebastian Meyer hält am 23. November 2018 um 14:00 Uhr im HS 436 der NW-Fakultät einen Gastvortrag zum Thema "Biodiversity-ecosystem functioning relationships and their drivers in natural and anthropogenic systems with an emphasis on species interactions". Der Fachbereich Biowissenschaften lödt herzlich dazu ein!
    The workshop aims to examine the musicality of the body and vice versa the corporeality of music from a choreographic perspective. This approach corresponds with the extension of the concept of music as well as the questioning of performance traditions in the context of New Music, which also puts a stronger emphasis on the body.
    The relatively young democracy Poland, whose political climate has intensified considerably since the last elections, is also moving increasingly to the fore. Politically critical leaders of representative cultural organisations have been and continue to be replaced by the new administration, while independent creative artists appear to be able to find niches so far or already live outside the country.
    Vom 29.11. bis 01.12.2018 im Unipark Nonntal
    Das Symposion der Katholische-Theologischen Fakultät findet am 29. und 30. November anlässlich der Aufhebung im Jahre 1938 statt. Veranstaltungsort ist der Hörsaal 101 der Theologischen Fakultät, Universitätsplatz 1.
    Salzburger Innovationstagung 2018 am 29.11.2018 ab 15 Uhr in der Großen Universitätsaula – ITG, Land Salzburg, Wirtschaftskammer und Salzburger Hochschulkonferenz
    Am 30. November im Rahmen der Tagung Digital Humanities Austria 2018
    Am 6. Dezember 2018 finden an der Universität Salzburg die WTZ Training Days zum Thema Kommunikation, Dissemination und Verbreitung in H2020-Projekten statt.
  • Veranstaltungen
  • 19.11.18 Medeas furor: Christliche Mythenkritik in Dracontius' Romulea?
    21.11.18 Zeit und Kult in der Gründungsphase der neuen Polis Rhodos
    22.11.18 Affine vs. Euclidean isoperimetric inequalities
  • Alumni Club
  • Uni-Shop
  • Facebook-Auftritt der Universität Salzburg Twitter-Auftritt der Universität Salzburg Instagram-Auftritt der Universität Salzburg Flickr-Auftritt der Universität Salzburg Vimeo-Auftritt der Universität Salzburg